{"id":"W2570449624","doi":"10.1002/cmdc.201600482","title":"Design of a Mestranol 2‐<i>N</i>‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Northeast Ohio Medical University","keywords":"MCF-7; In vivo; In vitro; Mestranol; Breast cancer; Chemistry; Cancer research; Pharmacology; Internal medicine; Cancer; Medicine; Stereochemistry; Biology; Biochemistry; Human breast; Population; Genetics; Research methodology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008775243,0.0003534091,0.000208767,0.0001341784,0.00008608664,0.0001398125,0.0003266061,0.0001823224,0.001632671],"category_scores_gemma":[0.00005922803,0.0001586436,0.0001728962,0.0001146407,0.0001094253,0.0001626666,0.0001243698,0.0003036703,0.0005843354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001964863,"about_ca_system_score_gemma":0.0002385265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004695377,"about_ca_topic_score_gemma":0.0007346583,"domain_scores_codex":[0.9999597,0.000005967373,0.000004260088,0.00001018255,0.00000746118,0.00001238419],"domain_scores_gemma":[0.9999673,0.000002114656,0.00001188076,0.000003049604,0.000005380917,0.00001017582],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001864839,0.0000646888,0.00009104168,0.00008886784,0.000006357421,0.0001040203,0.00001636539,0.0004169933,0.9940719,0.0002502888,0.00007894231,0.004623895],"study_design_scores_gemma":[0.0001652232,0.00248033,0.001425217,0.00001143749,0.00003954261,0.0004022866,0.00001837103,0.001208755,0.9848593,0.00004666115,0.009328038,0.00001489683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849387,0.001814969,0.006554317,0.0002042781,0.00003683856,0.00031805,0.000674213,0.0001760517,0.005282457],"genre_scores_gemma":[0.9836662,0.001916693,0.008759527,0.00009445868,0.00001358071,0.0001359815,0.0007604085,0.00002632857,0.004626841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001632671,"threshold_uncertainty_score":0.005461812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596418789455925,"score_gpt":0.2486729660789886,"score_spread":0.2327087781844293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}