{"id":"W2570449624","doi":"10.1002/cmdc.201600482","title":"Design of a Mestranol 2‐<i>N</i>‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Northeast Ohio Medical University","keywords":"MCF-7; In vivo; In vitro; Mestranol; Breast cancer; Chemistry; Cancer research; Pharmacology; Internal medicine; Cancer; Medicine; Stereochemistry; Biology; Biochemistry; Human breast; Population; Genetics; Research methodology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000148583,0.0001791464,0.0002683988,0.0000812847,0.00005516924,0.00002134164,0.0001126372,0.0002234833,9.96175e-7],"category_scores_gemma":[0.00002892003,0.0001715965,0.00002718899,0.00007245931,0.000196034,0.00002939666,0.00008780408,0.0001911131,5.91858e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004739801,"about_ca_system_score_gemma":0.0001072268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003402778,"about_ca_topic_score_gemma":0.0001041096,"domain_scores_codex":[0.9991203,0.0000488417,0.0001774877,0.0003262119,0.00007506483,0.0002520928],"domain_scores_gemma":[0.9996271,0.00002594235,0.00009311696,0.0001716698,0.00002735238,0.00005484197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006463781,0.00007430728,0.007164714,0.00004255681,0.00004376744,0.00001887551,0.0007403421,0.0005317153,0.9891573,0.000005908147,0.000008591964,0.00156561],"study_design_scores_gemma":[0.001547717,0.00003825044,0.01354855,0.0001267,0.00001137498,0.00002513075,0.0001789829,0.00277963,0.9814537,0.0001089104,0.000001442046,0.0001796145],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975365,0.001586827,0.0002002146,0.00009946583,0.00002287269,0.0003022495,0.00001647094,0.000004038075,0.0002313241],"genre_scores_gemma":[0.9985182,0.001000496,0.000325903,0.00002745876,0.00002050023,0.00006753684,0.000005200403,0.0000167488,0.00001790293],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007703536,"threshold_uncertainty_score":0.6997502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01596418789455925,"score_gpt":0.2486729660789886,"score_spread":0.2327087781844293,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}