{"id":"W2570660231","doi":"10.1038/ncomms13671","title":"Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Health and Medical Research Council; National Breast Cancer Foundation; Prostate Cancer Canada; Government of Ontario; Prostate Cancer Foundation; Ontario Institute for Cancer Research; Medical Research Council; Movember Foundation; Canadian Institutes of Health Research; Prostate Cancer Foundation of Australia; Genome Canada","keywords":"Prostate cancer; Germline; Biology; BRCA2 Protein; Germline mutation; Genome instability; Cancer research; Genetics; Cancer; Mutation; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456619,0.0001621053,0.0002149675,0.0006962536,0.0003259472,0.0003740477,0.0001779018,0.000257283,0.001172905],"category_scores_gemma":[0.0003448504,0.0001797798,0.0001486961,0.0005327282,0.0002137938,0.0001551116,0.0004771224,0.0003127082,0.0001501967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411043,"about_ca_system_score_gemma":0.0002553794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413426,"about_ca_topic_score_gemma":0.003601169,"domain_scores_codex":[0.9998394,0.00002495703,0.000006227815,0.00004815235,0.00004287699,0.00003831702],"domain_scores_gemma":[0.9998154,0.00002846037,0.00008563633,0.00001508275,0.00001841485,0.00003690176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007806512,0.00009670525,0.534836,0.00008593796,0.0002244456,0.002198551,0.001076742,0.001045209,0.4209976,0.001132369,0.0004122497,0.03711361],"study_design_scores_gemma":[0.00000964655,0.0002077705,0.9819937,0.00001205974,0.00004912541,0.004740051,0.0003788711,0.0006923217,0.009501606,0.0004611617,0.001935874,0.00001778397],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998244,0.0005235489,0.0003379673,0.00003811012,0.000001916187,0.000005445376,0.0001664793,0.00001467681,0.0006678181],"genre_scores_gemma":[0.9983285,0.0004779504,0.0003898575,0.00003526764,0.000004078595,0.000006745657,0.0002494244,0.00001103934,0.0004970785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001413426,"threshold_uncertainty_score":0.003923714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823043198025306,"score_gpt":0.3651493387575306,"score_spread":0.3369189067772776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}