{"id":"W2570660231","doi":"10.1038/ncomms13671","title":"Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; Princess Margaret Cancer Centre; University Health Network","funders":"National Health and Medical Research Council; National Breast Cancer Foundation; Prostate Cancer Canada; Government of Ontario; Prostate Cancer Foundation; Ontario Institute for Cancer Research; Medical Research Council; Movember Foundation; Canadian Institutes of Health Research; Prostate Cancer Foundation of Australia; Genome Canada","keywords":"Prostate cancer; Germline; Biology; BRCA2 Protein; Germline mutation; Genome instability; Cancer research; Genetics; Cancer; Mutation; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.00009436766,0.0001481077,0.0001946761,0.00008787258,0.001693448,0.00007709016,0.0006205883,0.0001351146,0.00004281864],"category_scores_gemma":[0.0002050908,0.0001058585,0.00006405164,0.000168186,0.0009338853,0.0002225021,0.0001904227,0.0008589179,0.00001822971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985026,"about_ca_system_score_gemma":0.0008149938,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003390808,"about_ca_topic_score_gemma":0.002693545,"domain_scores_codex":[0.9990507,0.00004781569,0.0001571911,0.0002205609,0.0002814975,0.0002422657],"domain_scores_gemma":[0.9968095,0.0001329903,0.0001372267,0.002291872,0.0004860188,0.0001424291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001006039,0.0006734067,0.9650747,0.0001133604,0.0007730598,0.0000840945,0.002891704,0.00002399462,0.0009431489,0.009088482,0.01199393,0.007334103],"study_design_scores_gemma":[0.002227388,0.0002478051,0.9361846,0.0001711874,0.0001870464,0.00005096169,0.0003000842,0.0003735897,0.0003554147,0.000313606,0.05941039,0.000177914],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6802507,0.04521584,0.0001556884,0.1536271,0.0006469977,0.004614574,0.001381027,0.0005604792,0.1135475],"genre_scores_gemma":[0.9882513,0.001274288,0.00484626,0.0001139366,0.0000928412,0.0002950497,0.0009638235,0.00002528103,0.004137197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3080006,"threshold_uncertainty_score":0.9996062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02823043198025306,"score_gpt":0.3651493387575306,"score_spread":0.3369189067772776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}