{"id":"W2570921152","doi":"10.1182/blood.v114.22.861.861","title":"Safety and Efficacy of Subcutaneous-Administered Omacetaxine Mepesuccinate in Chronic Myeloid Leukemia (CML) Patients Who Are Resistant or Intolerant to Two or More Tyrosine Kinase Inhibitors – Results of A Multicenter Phase 2/3 Study.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Dasatinib; Adverse effect; Gastroenterology; Dosing; Regimen; Clinical trial; Myeloid leukemia; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001066277,0.0006018032,0.001106233,0.0001794007,0.0002303751,0.0004669408,0.0003529105,0.0006883355,0.001403235],"category_scores_gemma":[0.0008905665,0.0002651433,0.00067137,0.000279088,0.0004696802,0.0005472059,0.0001714813,0.00129833,0.0003857046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003257475,"about_ca_system_score_gemma":0.0004839868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003355945,"about_ca_topic_score_gemma":0.0005458856,"domain_scores_codex":[0.9997023,0.0001527329,0.00002162785,0.00004466567,0.0000354751,0.00004320802],"domain_scores_gemma":[0.9993519,0.0001438847,0.0002007986,0.00005156216,0.00002930167,0.0002224468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6927204,0.03731293,0.04482037,0.0006298264,0.001223455,0.0005637483,0.000321145,0.001927567,0.08367541,0.0001261018,0.001677275,0.1350017],"study_design_scores_gemma":[0.2193989,0.6840177,0.08490179,0.00003401172,0.0005268393,0.0007949842,0.00007017561,0.001832459,0.006631872,0.00009587478,0.001673272,0.00002217032],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985922,0.0005844182,0.0001166947,0.00006052788,0.00001229749,0.0002039266,0.0001373885,0.00001207653,0.0002806307],"genre_scores_gemma":[0.9982102,0.0003597306,0.0002807466,0.0001440098,0.00004803058,0.0001862126,0.0004851731,0.000007316281,0.0002784189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403235,"threshold_uncertainty_score":0.005639136,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593925178212615,"score_gpt":0.3040364988504327,"score_spread":0.2880972470683065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}