{"id":"W2570921152","doi":"10.1182/blood.v114.22.861.861","title":"Safety and Efficacy of Subcutaneous-Administered Omacetaxine Mepesuccinate in Chronic Myeloid Leukemia (CML) Patients Who Are Resistant or Intolerant to Two or More Tyrosine Kinase Inhibitors – Results of A Multicenter Phase 2/3 Study.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Internal medicine; Dasatinib; Adverse effect; Gastroenterology; Dosing; Regimen; Clinical trial; Myeloid leukemia; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003604409,0.0005611001,0.001486843,0.0004446426,0.00007226518,0.0000186492,0.0002237073,0.0001483206,0.00004767784],"category_scores_gemma":[0.000791481,0.0004039376,0.0001322368,0.000777867,0.0001135169,0.0001005773,0.0001492679,0.0003090528,0.000004544323],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001710255,"about_ca_system_score_gemma":0.0008544034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005887356,"about_ca_topic_score_gemma":0.001984908,"domain_scores_codex":[0.9958426,0.0001656982,0.001776801,0.0008970419,0.0007056727,0.0006122202],"domain_scores_gemma":[0.9974609,0.0002369302,0.0006646247,0.0009631917,0.0002795836,0.0003947927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7025066,0.05802778,0.03592619,0.001743775,0.001270239,0.01377585,0.01497396,0.0001550975,0.09010214,0.000005593156,0.0003634818,0.08114933],"study_design_scores_gemma":[0.4770002,0.05998458,0.3647663,0.005217567,0.001163489,0.0001505953,0.000894677,0.0004243692,0.08932187,0.00000144758,0.0004438088,0.0006311288],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994837,0.0005298203,0.000001970852,0.0003413018,0.00007219705,0.003663991,0.0004093611,0.00004751625,0.00009688464],"genre_scores_gemma":[0.998508,0.0001512903,0.0004348954,0.0001213618,0.00009161662,0.00003560024,0.0001227834,0.00005778497,0.0004767195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3288401,"threshold_uncertainty_score":0.9998413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593925178212615,"score_gpt":0.3040364988504327,"score_spread":0.2880972470683065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}