{"id":"W2571057012","doi":"10.1158/1078-0432.ccr-16-1496","title":"Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+-Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC)","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Queen's University","funders":"","keywords":"Medicine; Internal medicine; Rash; Gastroenterology; Nausea; Cohort; Anemia; Metastatic breast cancer; Pharmacokinetics; Diarrhea; Vomiting; Neutropenia; Breast cancer; Cancer; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008009276,0.0009221596,0.00101409,0.0002137909,0.0002475603,0.0003624487,0.0005067965,0.0003692811,0.001821828],"category_scores_gemma":[0.0004143074,0.0003046728,0.0004817179,0.0002413584,0.0005249552,0.0005028925,0.0002743683,0.001435505,0.0003221594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007356457,"about_ca_system_score_gemma":0.0009837662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001076955,"about_ca_topic_score_gemma":0.002828832,"domain_scores_codex":[0.9997979,0.00007510295,0.00001048166,0.00003660518,0.00003108292,0.00004886944],"domain_scores_gemma":[0.9996158,0.00005174219,0.00005706566,0.0000397074,0.00002468297,0.0002109289],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4462852,0.1413963,0.03314733,0.0006607147,0.0008914559,0.0008682413,0.0008376227,0.006754481,0.1785943,0.000476,0.004747486,0.1853409],"study_design_scores_gemma":[0.1481075,0.7966551,0.03746985,0.00002359291,0.0003108341,0.0007454402,0.00009567702,0.002458066,0.01108035,0.000149969,0.002878741,0.000025022],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986771,0.0002128457,0.0001408462,0.0000407593,0.000008708501,0.0003608547,0.0001679537,0.00001894813,0.0003720002],"genre_scores_gemma":[0.9960682,0.0002990255,0.0008925598,0.0001230677,0.00003380806,0.0006067374,0.001060258,0.00001031416,0.000905979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001821828,"threshold_uncertainty_score":0.006094575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1875389917310509,"score_gpt":0.5709110171428204,"score_spread":0.3833720254117696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}