{"id":"W2571057012","doi":"10.1158/1078-0432.ccr-16-1496","title":"Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+-Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC)","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Queen's University","funders":"","keywords":"Medicine; Internal medicine; Rash; Gastroenterology; Nausea; Cohort; Anemia; Metastatic breast cancer; Pharmacokinetics; Diarrhea; Vomiting; Neutropenia; Breast cancer; Cancer; Toxicity","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.006181791,0.000495707,0.001922754,0.0006676975,0.000336507,0.000136112,0.001113843,0.0002091668,0.0005169245],"category_scores_gemma":[0.001032622,0.0003606832,0.0001133808,0.001186042,0.001498074,0.0006372888,0.0005003688,0.002998027,0.00001584952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001471157,"about_ca_system_score_gemma":0.004492573,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.059951,"about_ca_topic_score_gemma":0.1126481,"domain_scores_codex":[0.9893198,0.001583817,0.001773013,0.001694983,0.004015847,0.001612565],"domain_scores_gemma":[0.9935072,0.0005326508,0.000516418,0.002528101,0.001926191,0.0009894167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.03307132,0.02199348,0.8827931,0.0003911526,0.0002158322,0.0006117907,0.0009782274,0.0001128091,0.0001334227,0.000002531816,0.000239896,0.05945647],"study_design_scores_gemma":[0.0518661,0.03162545,0.9101379,0.00317887,0.00008426544,0.000006702971,0.001797241,0.0002887277,0.0004235372,0.00002405254,0.0001731701,0.0003940011],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991981,0.0002558286,0.000003811168,0.0009717011,0.0001917323,0.006181102,0.0001673865,0.00003688776,0.0002105964],"genre_scores_gemma":[0.9962891,0.0004397437,0.0002177601,0.0001145997,0.0003005383,0.002141967,0.00003421227,0.0001654071,0.000296707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05906247,"threshold_uncertainty_score":0.9998845,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1875389917310509,"score_gpt":0.5709110171428204,"score_spread":0.3833720254117696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}