{"id":"W2571229748","doi":"10.1002/cncr.30515","title":"Imidazoquinoxaline derivative EAPB0503: A promising drug targeting mutant nucleophosmin 1 in acute myeloid leukemia","year":2017,"lang":"en","type":"article","venue":"Cancer","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"NPM1; Nucleophosmin; Myeloid leukemia; Cancer research; Leukemia; Molecular biology; Propidium iodide; Flow cytometry; Apoptosis; Biology; Chemistry; Cell biology; Programmed cell death; Biochemistry; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009440885,0.0002567767,0.0002493547,0.0002349745,0.0001107314,0.0001231758,0.0003659643,0.0002131268,0.0007709872],"category_scores_gemma":[0.00004506767,0.00004881624,0.0001209729,0.0001737094,0.0001217875,0.0001064981,0.0000948446,0.0002864753,0.0002854218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002321563,"about_ca_system_score_gemma":0.000150409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005163279,"about_ca_topic_score_gemma":0.001102622,"domain_scores_codex":[0.9999657,0.000006631229,0.000002563742,0.000006357461,0.000009076989,0.000009613405],"domain_scores_gemma":[0.999981,0.000002256952,0.000004773859,0.00000130055,0.00000357371,0.00000705641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008684995,0.0003465847,0.0007005292,0.0004242152,0.00002692951,0.000374073,0.00003599511,0.0008270344,0.925988,0.0008626296,0.002304896,0.06724069],"study_design_scores_gemma":[0.002054503,0.009656924,0.01964642,0.0001133366,0.000204218,0.006013518,0.00005394997,0.0074105,0.8845447,0.0005146007,0.06973434,0.00005297323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9355848,0.04752559,0.005872536,0.000668711,0.0001374409,0.0001923184,0.0009762581,0.0004785782,0.008563831],"genre_scores_gemma":[0.9777035,0.01330102,0.004303752,0.000254389,0.000038535,0.00008789705,0.001290691,0.00002208947,0.002998077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007709872,"threshold_uncertainty_score":0.002579212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02394720272797526,"score_gpt":0.335646800345947,"score_spread":0.3116995976179717,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}