{"id":"W2571241168","doi":"10.1016/j.stem.2016.12.004","title":"New Insights into Early Human Development: Lessons for Stem Cell Derivation and Differentiation","year":2017,"lang":"en","type":"review","venue":"Cell stem cell","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":265,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Health and Medical Research Council","keywords":"Biology; Embryonic stem cell; Induced pluripotent stem cell; Stem cell; Cell biology; Embryo; Cellular differentiation; Developmental biology; Directed differentiation; Evolutionary biology; Neuroscience; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001638879,0.001096607,0.001442397,0.001671338,0.0003519313,0.001375425,0.001447347,0.001674526,0.003034625],"category_scores_gemma":[0.001637997,0.0003151763,0.0004507594,0.001653919,0.001787228,0.002629476,0.001188969,0.003602444,0.001784567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001330297,"about_ca_system_score_gemma":0.001800077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001187901,"about_ca_topic_score_gemma":0.002314994,"domain_scores_codex":[0.9997305,0.00004892719,0.00003554874,0.00005264,0.0001000465,0.00003237475],"domain_scores_gemma":[0.9992158,0.0004571282,0.00004621911,0.00002917784,0.000182907,0.00006862303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009222276,0.00004160665,0.0001747252,0.01224456,0.00006252954,0.0002692977,0.0001003972,0.0004365723,0.002275539,0.02355387,0.05936435,0.9013844],"study_design_scores_gemma":[0.000008827326,0.00002362184,0.0001938818,0.00163418,0.00003648143,0.0004637317,0.00005585505,0.00003891216,0.000591866,0.006155804,0.9907833,0.00001335211],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005180812,0.9976102,0.0003269696,0.0007848408,0.0005016511,0.000002118749,0.0000183945,0.00000821333,0.0006957606],"genre_scores_gemma":[0.0004194605,0.9980912,0.0002565835,0.0004716732,0.0002946633,0.000003878376,0.00002178253,0.00000292713,0.0004377955],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003034625,"threshold_uncertainty_score":0.0101518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07163222810813571,"score_gpt":0.3294096731578833,"score_spread":0.2577774450497475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}