{"id":"W2571258660","doi":"10.1186/s13063-016-1731-4","title":"The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given ‘as needed’ in mild asthma: study protocols for two randomised controlled trials","year":2017,"lang":"en","type":"article","venue":"Trials","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; St. Joseph’s Healthcare Hamilton; McMaster University","funders":"National Institute for Health and Care Research; AstraZeneca","keywords":"Budesonide; Formoterol; Budesonide/formoterol; Medicine; Terbutaline; Placebo; Asthma; Randomized controlled trial; Clinical trial; Pediatrics; Physical therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.1260344,0.0004226204,0.007806784,0.000184993,0.0005237151,0.0001848206,0.0005565776,0.0001274451,0.00005732045],"category_scores_gemma":[0.2447774,0.0001737985,0.001385198,0.0001425942,0.0003348085,0.00009637127,0.0001140521,0.0001608749,0.000003877066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000444922,"about_ca_system_score_gemma":0.0006121329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00016691,"about_ca_topic_score_gemma":0.00006036479,"domain_scores_codex":[0.9801513,0.01108858,0.006756059,0.0005212597,0.0009014701,0.0005813297],"domain_scores_gemma":[0.9556915,0.03793417,0.004206673,0.001324173,0.0005360801,0.0003074694],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8149216,0.002630886,0.0002901664,0.000163048,0.001636257,0.00000763751,0.001193871,0.00001292924,0.01715294,0.00006169894,0.0004347335,0.1614943],"study_design_scores_gemma":[0.9655114,0.01134295,0.002171178,0.0006904939,0.002751717,0.000002670407,0.001873365,0.0001153465,0.009717078,0.0002023345,0.005419837,0.000201565],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6344908,0.0005353732,0.0001195991,0.00239101,0.000181058,0.3620588,0.0001152739,0.00002096161,0.00008709531],"genre_scores_gemma":[0.9111536,0.0000322856,0.00009724768,0.0001545709,0.0006981684,0.08763041,0.000007370387,0.00004234585,0.0001840092],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2766628,"threshold_uncertainty_score":0.8999315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2024827557136186,"score_gpt":0.5057645965740613,"score_spread":0.3032818408604426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}