{"id":"W2571409851","doi":"10.1182/blood.v110.11.5136.5136","title":"Mesenchymal Stromal Cells Gene-Enhanced To Express Human Factor IX and Their In Vivo Use for Correction of Hemophilia B Phenotype in R333Q Mice.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Jewish General Hospital; McGill University","funders":"","keywords":"Factor IX; Mesenchymal stem cell; Genetic enhancement; Medicine; In vivo; Immunology; Cell therapy; Pharmacology; Cancer research; Stem cell; Pathology; Internal medicine; Biology; Gene; Biotechnology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003453074,0.0004720773,0.0002097253,0.0004260348,0.0001418213,0.000250218,0.0002035835,0.0005474127,0.001429196],"category_scores_gemma":[0.0001197569,0.0001999818,0.000321741,0.0001724719,0.0003048303,0.0001544532,0.0001290702,0.0008389533,0.0005672559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002064837,"about_ca_system_score_gemma":0.0001722114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007573944,"about_ca_topic_score_gemma":0.0007981179,"domain_scores_codex":[0.9996641,0.00007353984,0.00003436227,0.00005222304,0.000109677,0.00006616201],"domain_scores_gemma":[0.9997461,0.00003745224,0.00009857672,0.00002888313,0.0000181659,0.0000708828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096314,0.00007216768,0.00006817839,0.00001014969,0.000003367762,0.00003476656,0.00001023556,0.00003026081,0.9990533,0.00005923949,0.00002698456,0.0005217116],"study_design_scores_gemma":[0.00007925158,0.001522451,0.002920737,0.000007034279,0.00001940766,0.0002982933,0.00002518397,0.0008786216,0.9923016,0.00003032586,0.001912158,0.000004937236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943191,0.0007000235,0.00291169,0.0001225921,0.00005182759,0.0001046498,0.0005712167,0.0001452211,0.001073661],"genre_scores_gemma":[0.9917123,0.0005339193,0.003093383,0.00006015664,0.00001273257,0.00009532292,0.0006617994,0.00004280272,0.003787564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001429196,"threshold_uncertainty_score":0.004781127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01814316009132306,"score_gpt":0.2862565669745742,"score_spread":0.2681134068832511,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}