{"id":"W2571541186","doi":"10.4049/jimmunol.1600742","title":"HIV-1 Latency-Reversing Agents Prostratin and Bryostatin-1 Induce Blood–Brain Barrier Disruption/Inflammation and Modulate Leukocyte Adhesion/Transmigration","year":2016,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research","keywords":"Inflammation; Latency (audio); Reversing; Bryostatin 1; Human immunodeficiency virus (HIV); Adhesion; Immunology; Blood–brain barrier; Medicine; Chemistry; Neuroscience; Cell biology; Biology; Central nervous system; Signal transduction; Protein kinase C; Computer science; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009262918,0.0002079656,0.0001848997,0.0001005664,0.00006948923,0.0001798804,0.00009196573,0.0001378062,0.0008216324],"category_scores_gemma":[0.00007452538,0.00006123354,0.0001823247,0.0001001163,0.0001147796,0.0001512717,0.0001101332,0.0005027226,0.0001018789],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001304489,"about_ca_system_score_gemma":0.0001008207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000336807,"about_ca_topic_score_gemma":0.0004075061,"domain_scores_codex":[0.9999338,0.00001432712,0.000005679204,0.000007102723,0.00001430171,0.00002475293],"domain_scores_gemma":[0.9999642,0.000009093525,0.00001136377,0.000004322987,0.000003354669,0.00000768976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001308786,0.00002742912,0.0001442046,0.00002202769,0.000004367445,0.00001931391,0.000006819931,0.00003470235,0.998406,0.00004282794,0.00002704202,0.001134312],"study_design_scores_gemma":[0.00001858971,0.0009733578,0.005161676,0.000003558232,0.00001642332,0.00009760702,0.00002711783,0.0006827241,0.9921564,0.00003071417,0.0008294248,0.000002325898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959376,0.001456354,0.001794204,0.00005717835,0.00001845193,0.00001741769,0.0002279462,0.00003308503,0.0004578526],"genre_scores_gemma":[0.9965019,0.0009231479,0.001732571,0.00004401103,0.000008913245,0.00002352026,0.0002381807,0.000004199107,0.0005234697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008216324,"threshold_uncertainty_score":0.002748609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425219469616698,"score_gpt":0.2493725101536487,"score_spread":0.2351203154574817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}