{"id":"W2572023600","doi":"10.1182/blood.v106.11.3362.3362","title":"LS104, a Novel Kinase Inhibitor, Induces Apoptosis, Synergizes with Cytostatic Drugs and Is Targeting the Receptor Tyrosine Kinase FLT3.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fms-Like Tyrosine Kinase 3; Myeloid leukemia; Tyrosine kinase; Biology; Cancer research; Molecular biology; Tyrosine-kinase inhibitor; Annexin; Cytotoxic T cell; Receptor tyrosine kinase; Kinase; Cell biology; Signal transduction; Flow cytometry; Biochemistry; Mutation; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001109462,0.0002546841,0.0001958094,0.00002026674,0.0003609074,0.0001053452,0.0002268643,0.0001138516,0.0003175497],"category_scores_gemma":[0.00007314571,0.0001846169,0.0000505758,0.0002065365,0.0001742465,0.0001152659,0.00009794607,0.0002850108,0.00002262827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002368687,"about_ca_system_score_gemma":0.00004978647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003722044,"about_ca_topic_score_gemma":0.000004609315,"domain_scores_codex":[0.9987586,0.000009012931,0.0002837419,0.0004154799,0.0002273888,0.0003058253],"domain_scores_gemma":[0.9990573,0.0001700453,0.0001563551,0.0004117357,0.00006881984,0.0001357733],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002270884,0.0005757777,0.0002326318,0.0001129771,0.00006106783,8.078021e-7,0.0009946714,0.000004422196,0.9948643,0.00009098282,0.001930318,0.001109359],"study_design_scores_gemma":[0.001523494,0.00001729159,0.0000202315,0.0001407047,0.0001329285,0.00001314248,0.001128774,0.00002635262,0.9731054,0.00002014387,0.0236028,0.0002687614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993135,0.0008134815,0.00001270123,0.003662603,0.00001301085,0.0001109838,0.0001370631,0.00009971211,0.002015495],"genre_scores_gemma":[0.9957685,0.0001215992,0.002009461,0.0002969817,0.0005797343,0.0001450653,0.00008551651,0.00003717006,0.0009559793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0217589,"threshold_uncertainty_score":0.7528459,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008659193478486765,"score_gpt":0.2217861616129125,"score_spread":0.2131269681344257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}