{"id":"W2572023600","doi":"10.1182/blood.v106.11.3362.3362","title":"LS104, a Novel Kinase Inhibitor, Induces Apoptosis, Synergizes with Cytostatic Drugs and Is Targeting the Receptor Tyrosine Kinase FLT3.","year":2005,"lang":"en","type":"article","venue":"Blood","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Fms-Like Tyrosine Kinase 3; Myeloid leukemia; Tyrosine kinase; Biology; Cancer research; Molecular biology; Tyrosine-kinase inhibitor; Annexin; Cytotoxic T cell; Receptor tyrosine kinase; Kinase; Cell biology; Signal transduction; Flow cytometry; Biochemistry; Mutation; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007919466,0.0004948734,0.0002199135,0.0003753114,0.0001060061,0.0001700507,0.0001997152,0.0003000577,0.00126663],"category_scores_gemma":[0.00007904822,0.0001127205,0.0002053634,0.0002028722,0.0001452767,0.0001223061,0.0001136393,0.000381922,0.0004255185],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002158082,"about_ca_system_score_gemma":0.0001577998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002728311,"about_ca_topic_score_gemma":0.0005326396,"domain_scores_codex":[0.9999293,0.00001565634,0.000006044041,0.00001003825,0.00002394298,0.00001501088],"domain_scores_gemma":[0.9999571,0.000008636356,0.00001357661,0.000003741763,0.00000437815,0.00001248779],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002997772,0.0001702108,0.0001447395,0.00007907072,0.00001318841,0.00008127156,0.000007897873,0.0001925115,0.9917465,0.00007916141,0.0002605058,0.006924939],"study_design_scores_gemma":[0.000143437,0.003040019,0.00284772,0.000007995872,0.00002854399,0.0005256328,0.000007591168,0.000848822,0.9870616,0.00002746091,0.005454641,0.000006476477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851496,0.005795995,0.002168124,0.0002308411,0.0001138481,0.0001128627,0.000513108,0.0004890184,0.005426642],"genre_scores_gemma":[0.989907,0.003038927,0.001523974,0.00008435381,0.00004098292,0.00008145313,0.001272719,0.00002606584,0.004024612],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00126663,"threshold_uncertainty_score":0.004237294,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008659193478486765,"score_gpt":0.2217861616129125,"score_spread":0.2131269681344257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}