{"id":"W257211957","doi":"10.1096/fasebj.23.1_supplement.637.1","title":"Activation of Hypoxia‐Inducible Factor‐1 by Sphingosine‐1‐Phosphate in vascular cells","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Sphingosine-1-phosphate; Angiogenesis; Cell biology; Hypoxia-Inducible Factor 1; Inducer; Activator (genetics); Cellular adaptation; Sphingosine; Hypoxia (environmental); Hypoxia-inducible factors; Vascular smooth muscle; Biology; Transcription factor; Chemistry; Receptor; Cancer research; Biochemistry; Gene; Endocrinology; Oxygen","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295448,0.0002050751,0.0002045941,0.0001672084,0.0001456669,0.0002120505,0.0001396658,0.0002501622,0.001022821],"category_scores_gemma":[0.00007976188,0.0001332469,0.0002205716,0.0001702129,0.0001363374,0.0001635813,0.0001326509,0.0003346434,0.0003806384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002394125,"about_ca_system_score_gemma":0.0001438677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005285434,"about_ca_topic_score_gemma":0.0005410629,"domain_scores_codex":[0.9999192,0.00002545373,0.000005916851,0.000014309,0.00001579286,0.0000193275],"domain_scores_gemma":[0.9999609,0.00001053955,0.000006450627,0.000005978933,0.000005941497,0.00001017612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001075041,0.0000219211,0.00007164678,0.00005095788,0.000002716762,0.00004263399,0.0000162127,0.00004985917,0.9980611,0.00009527225,0.00004967312,0.001430335],"study_design_scores_gemma":[0.00003110347,0.0003214396,0.003611039,0.000006214202,0.000009416198,0.0002276107,0.00002323248,0.0009223595,0.9910822,0.0001036099,0.0036576,0.000004166157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758346,0.01134193,0.007771262,0.000425146,0.00009390219,0.00005923421,0.0008114655,0.0001288477,0.003533608],"genre_scores_gemma":[0.9868484,0.004880631,0.004087598,0.000127254,0.00004468017,0.00009588451,0.001033923,0.00001198835,0.00286961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001022821,"threshold_uncertainty_score":0.003421664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075456206358629,"score_gpt":0.2295480524830704,"score_spread":0.2187934904194841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}