{"id":"W2572471102","doi":"10.1182/blood.v110.11.5027.5027","title":"Should Patients with Myelodysplasia and/or Acute Myeloid Leukemia (MDS/AML) Be Screened for Inherited RUNX1 Mutations Prior to Sibling Donor Allografting?.","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital","funders":"","keywords":"RUNX1; Medicine; Proband; Sibling; Platelet disorder; CEBPA; Myeloid leukemia; Leukemia; Bone marrow; Myeloid; Internal medicine; Oncology; Genetics; Immunology; Mutation; Haematopoiesis; Biology; Stem cell; Gene; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006092733,0.0004141704,0.0005215182,0.0005790791,0.0006107794,0.0004978445,0.0004497802,0.002213683,0.002664982],"category_scores_gemma":[0.002177047,0.0001886037,0.0003198344,0.0003043434,0.0004577413,0.0007225326,0.0002263103,0.0009276749,0.0009454105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002668351,"about_ca_system_score_gemma":0.0005882339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001679773,"about_ca_topic_score_gemma":0.002643295,"domain_scores_codex":[0.9997132,0.00007215167,0.00004181988,0.00004188685,0.00005896119,0.00007185475],"domain_scores_gemma":[0.9991605,0.0002107478,0.0001144711,0.00003968303,0.0001520736,0.0003224886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001359318,0.0005181598,0.7503085,0.0003462076,0.00005096739,0.1154439,0.0006716984,0.0005401489,0.013244,0.0004704034,0.0186049,0.09844174],"study_design_scores_gemma":[0.0005761237,0.002704343,0.611971,0.0009249596,0.0002179947,0.3221984,0.004030006,0.003212776,0.01010121,0.003332959,0.0406322,0.00009800655],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9532613,0.006061406,0.002023578,0.02077542,0.0008014593,0.0002425173,0.0003789842,0.000202129,0.01625326],"genre_scores_gemma":[0.9859691,0.002034208,0.003403768,0.005686315,0.0009398491,0.0000738372,0.0002971853,0.0000218125,0.00157395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002664982,"threshold_uncertainty_score":0.008915246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02949248383752329,"score_gpt":0.3122175405950061,"score_spread":0.2827250567574828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}