{"id":"W2572608040","doi":"10.1182/blood.v120.21.3646.3646","title":"Results of a Phase 1 Dose-Escalation Study of Once-Weekly MLN9708, an Investigational Proteasome Inhibitor, in Patients with Relapsed/Refractory Lymphoma","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Medicine; Proteasome inhibitor; Bortezomib; Adverse effect; Pharmacodynamics; Refractory (planetary science); Cmax; Pharmacokinetics; Lymphoma; Internal medicine; Pharmacology; Multiple myeloma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002204441,0.0009411371,0.001899474,0.0004225635,0.0004162948,0.0007723015,0.0007550695,0.000754213,0.001662942],"category_scores_gemma":[0.001478351,0.0004816607,0.001082637,0.0004934133,0.0005428614,0.0007140903,0.0003114393,0.002454053,0.0006077341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000939046,"about_ca_system_score_gemma":0.0009147544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005574373,"about_ca_topic_score_gemma":0.001332681,"domain_scores_codex":[0.9991952,0.0003804103,0.0000647453,0.0001523172,0.0001050632,0.0001023119],"domain_scores_gemma":[0.9989921,0.0002747095,0.0002238875,0.0001339918,0.00008605306,0.0002892083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4740053,0.1013015,0.0578867,0.0008699598,0.002593792,0.0008097696,0.001008384,0.005541994,0.1148159,0.0001905899,0.003774896,0.2372012],"study_design_scores_gemma":[0.2167874,0.6515039,0.1118505,0.00004590429,0.001309275,0.001025867,0.0001584764,0.002793717,0.01018851,0.0002053412,0.004070194,0.0000609455],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963697,0.0009236411,0.0003307359,0.0001303948,0.00002420705,0.0009115006,0.0004843829,0.0000518365,0.0007734699],"genre_scores_gemma":[0.9957662,0.0004699975,0.001047327,0.0002894562,0.00004446958,0.000648008,0.001141442,0.00002114116,0.0005718865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002204441,"threshold_uncertainty_score":0.01165831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654471848669231,"score_gpt":0.2501366491684977,"score_spread":0.2335919306818054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}