{"id":"W2572611801","doi":"10.1016/j.ygyno.2017.01.016","title":"A final report of a phase I study of veliparib (ABT-888) in combination with low-dose fractionated whole abdominal radiation therapy (LDFWAR) in patients with advanced solid malignancies and peritoneal carcinomatosis with a dose escalation in ovarian and fallopian tube cancers","year":2017,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"PARP inhibition in cancer therapy","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute","keywords":"Medicine; Veliparib; Gastroenterology; Internal medicine; Vomiting; Leukopenia; Nausea; Neutropenia; Mucositis; PARP inhibitor; Anemia; Radiation therapy; Oncology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004082025,0.0002031686,0.0006870837,0.0003701895,0.00009497014,0.00001347001,0.000071268,0.0001601369,0.00001453024],"category_scores_gemma":[0.0001040957,0.0001592433,0.00001539037,0.0002658682,0.0003159056,0.0003045617,0.00002213642,0.0002338758,1.22061e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006869172,"about_ca_system_score_gemma":0.0006122844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001734967,"about_ca_topic_score_gemma":0.009466765,"domain_scores_codex":[0.9983098,0.0001764498,0.0005903655,0.0004188156,0.0002693561,0.0002351943],"domain_scores_gemma":[0.9984444,0.0001433808,0.0008303249,0.0002682414,0.0002493071,0.00006436608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02139108,0.004095309,0.9525571,0.00005641113,0.0000637704,0.0002507475,0.003770326,0.0005269528,0.001945889,0.00001016498,0.000002991755,0.0153292],"study_design_scores_gemma":[0.09073509,0.02242526,0.8837404,0.0001744699,0.00003798214,0.00007945863,0.001258424,0.0007735741,0.0005805457,0.00002731151,0.00002184208,0.0001456041],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997215,0.00006302272,0.00002881729,0.0003957348,0.0000611682,0.002119398,0.00001383634,0.00001049614,0.00009249862],"genre_scores_gemma":[0.9987117,0.00006985293,0.0006275439,0.00006234201,0.00001081872,0.0004336637,0.00005913014,0.00001600461,0.000008946919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06934401,"threshold_uncertainty_score":0.6493751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203187329849931,"score_gpt":0.3261234026123364,"score_spread":0.3058046696273433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}