{"id":"W2572661861","doi":"10.1182/blood.v118.21.966.966","title":"Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Dasatinib; Tyrosine kinase; Cancer research; Nilotinib; Imatinib mesylate; Myeloid leukemia; K562 cells; Stem cell; SH3 domain; Biology; Progenitor cell; Philadelphia chromosome; Imatinib; ABL; breakpoint cluster region; Leukemia; Cell biology; Signal transduction; Immunology; Receptor; Genetics; Gene; Chromosomal translocation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008755133,0.0001624953,0.0001021019,0.0001076108,0.0001329717,0.0001248729,0.0001908962,0.0001834253,0.0009824473],"category_scores_gemma":[0.00007547947,0.00006772231,0.0002346708,0.0001060997,0.0001278553,0.00009999942,0.0001076718,0.0003099763,0.000370599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000351045,"about_ca_system_score_gemma":0.0001112312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008667396,"about_ca_topic_score_gemma":0.0009004024,"domain_scores_codex":[0.9999515,0.000007483402,0.000002605969,0.000007446163,0.00001670114,0.00001426911],"domain_scores_gemma":[0.9999486,0.00001022621,0.00001466269,0.00000486614,0.000007890529,0.00001370176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001136371,0.00001920773,0.0003275164,0.00001651022,0.000002991442,0.00004512677,0.000008954171,0.00008791502,0.9988507,0.00009722642,0.00001973401,0.00041063],"study_design_scores_gemma":[0.00004573991,0.0003478045,0.0414083,0.00001147171,0.00002276276,0.0005599756,0.00007731219,0.004772504,0.9477578,0.000152367,0.004834571,0.000009468943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975958,0.0008259788,0.0004855711,0.00005518533,0.00001071828,0.00001105413,0.0002745072,0.000006598708,0.0007345774],"genre_scores_gemma":[0.9975631,0.0002298697,0.0003764544,0.00003446483,0.000004363492,0.000009165364,0.0008873363,0.000003679633,0.0008915036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009824473,"threshold_uncertainty_score":0.003286541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006730726741856921,"score_gpt":0.2000704274830921,"score_spread":0.1933397007412352,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}