{"id":"W2572768188","doi":"10.1021/jacs.6b11371","title":"Reversible Unfolding and Folding of the Metalloprotein Ferredoxin Revealed by Single-Molecule Atomic Force Microscopy","year":2017,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Force Microscopy Techniques and Applications","field":"Physics and Astronomy","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Canada Research Chairs; China Scholarship Council; Canada Foundation for Innovation","keywords":"Ferredoxin; Chemistry; Metalloprotein; Crystallography; Protein folding; Folding (DSP implementation); Molecule; Electron transfer; Biogenesis; Biophysics; Biochemistry; Photochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956183,0.0001218737,0.0002939815,0.000006420508,0.0003577096,0.00007058898,0.0007656165,0.00002919944,0.00001013568],"category_scores_gemma":[0.00002016415,0.0000755713,0.0004718664,0.0001061589,0.000555975,0.00009281355,0.0003177906,0.0002823395,2.312953e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006358731,"about_ca_system_score_gemma":0.00004236633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001529086,"about_ca_topic_score_gemma":2.028693e-7,"domain_scores_codex":[0.9992257,0.00002390577,0.0002998446,0.000124045,0.0001507876,0.0001757539],"domain_scores_gemma":[0.9980685,0.00003654464,0.001365791,0.000411611,0.00006379522,0.00005382359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008759942,0.00003815225,0.00567752,0.000007975036,0.00007200969,3.429227e-8,0.00008052997,8.289895e-7,0.98698,0.0001682337,0.006478045,0.0004878931],"study_design_scores_gemma":[0.0002331596,0.0000237516,0.0004011307,0.00009910227,0.0000732519,0.000003863423,0.0001620816,0.00005274756,0.9960373,0.001407339,0.001418334,0.00008793272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957871,0.00008553912,0.002318026,0.001343385,0.00003181402,0.0001447836,0.00002136797,0.000004604677,0.000263394],"genre_scores_gemma":[0.9910641,0.00001517399,0.008405627,0.0001456088,0.00006614478,0.000004284714,6.577059e-7,0.00001469793,0.0002836795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009057287,"threshold_uncertainty_score":0.3081708,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008962829910298975,"score_gpt":0.2734685366730755,"score_spread":0.2645057067627765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}