{"id":"W2573055599","doi":"10.1182/blood.v108.11.2218.2218","title":"Acetylation of a Conserved Lysine Residue within Activation Domain One of E2A Transcription Factors Plays a Role in Transcriptional Regulation.","year":2006,"lang":"en","type":"article","venue":"Blood","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Acetylation; Histone; Lysine; Transcription factor; Chromatin; Biology; P300-CBP Transcription Factors; Bromodomain; Histone H3; Transcriptional regulation; Transcription (linguistics); Activator (genetics); Cell biology; Molecular biology; Chemistry; Genetics; Gene; Histone Acetyltransferases; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002010568,0.0001313921,0.0001938228,0.0001555094,0.00003136242,0.000005923602,0.00006670524,0.0002313173,0.00002663681],"category_scores_gemma":[0.00002132226,0.0001481421,0.00009175944,0.0002479147,0.00006760519,0.00001911682,0.000007244638,0.00006695245,3.712018e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003189331,"about_ca_system_score_gemma":0.00009444381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004031557,"about_ca_topic_score_gemma":0.0008969761,"domain_scores_codex":[0.9987776,0.00009103274,0.0005326489,0.0002456674,0.0002303466,0.0001226475],"domain_scores_gemma":[0.9993632,0.00001401258,0.0002857639,0.0001910108,0.0001233969,0.00002261835],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003299823,0.000381638,0.01413084,0.0000407615,0.00005078355,8.593433e-8,0.0002294515,0.01077898,0.9731683,0.0008189343,0.00001547937,0.0000547226],"study_design_scores_gemma":[0.002030707,0.000114809,0.3246964,0.00004924202,0.00003728644,0.000001470799,0.00006132659,0.0002406357,0.6715827,0.001058656,0.00003471721,0.00009207426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950944,0.0002780679,0.003939746,0.00009867812,0.00003684056,0.0003149187,0.00004482297,0.00001048423,0.0001820189],"genre_scores_gemma":[0.9972405,0.00001217669,0.001438519,0.000005171785,0.00008832371,0.00001637107,0.00110209,0.00001827457,0.00007854558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3105656,"threshold_uncertainty_score":0.6041061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008289422073080581,"score_gpt":0.2001217193366046,"score_spread":0.191832297263524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}