{"id":"W2573057802","doi":"10.1101/100388","title":"Senescence associated protein degradation","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université du Québec à Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Senescence; Telomere; Cell biology; Proteasome; Protein degradation; Ubiquitin; Biology; MAPK/ERK pathway; Kinase; Genetics; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004390418,0.0007548001,0.0004866089,0.0008121549,0.0004662997,0.001112,0.0002581169,0.0005421751,0.007022198],"category_scores_gemma":[0.0003076228,0.0001881019,0.0004820596,0.0004931382,0.000219563,0.0004213291,0.0005772122,0.0009256459,0.006939923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006575123,"about_ca_system_score_gemma":0.0005284889,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002888707,"about_ca_topic_score_gemma":0.0002318037,"domain_scores_codex":[0.9997076,0.0000307388,0.00002964981,0.0001078812,0.00007424902,0.0000497424],"domain_scores_gemma":[0.9998258,0.00001120541,0.00003924,0.00004166156,0.00004671123,0.00003544373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003130487,0.00007077726,0.001678011,0.0005972256,0.00008003549,0.0005322491,0.00008837038,0.0001870748,0.9532556,0.003862369,0.008813649,0.03052167],"study_design_scores_gemma":[0.00004270432,0.0001459278,0.01127511,0.00009626861,0.00003785915,0.003269864,0.00005249611,0.001070341,0.7756721,0.003193345,0.2051248,0.00001911161],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.6250219,0.1728423,0.06807569,0.005665545,0.004411294,0.000421346,0.02540161,0.005413353,0.092747],"genre_scores_gemma":[0.8020089,0.03002201,0.01602895,0.0009669229,0.0005057866,0.0002052294,0.02178211,0.0003213822,0.1281586],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.007022198,"threshold_uncertainty_score":0.02349162,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02403362142389227,"score_gpt":0.2488735568244444,"score_spread":0.2248399354005521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}