{"id":"W2573089847","doi":"10.1016/j.clgc.2017.01.005","title":"Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma","year":2017,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Queen Elizabeth II Health Sciences Centre; University of Alberta; University of British Columbia; BC Cancer Agency; Dalhousie University","funders":"National Cancer Institute","keywords":"Medicine; Renal cell carcinoma; Oncology; Toxicity; VEGF receptors; Internal medicine; Targeted therapy; Second-line therapy; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00134717,0.0001192724,0.0005057195,0.0001752145,0.0002833739,0.000727184,0.0002670731,0.0003812463,0.001234533],"category_scores_gemma":[0.005429883,0.00005809238,0.0008364899,0.0002951394,0.0002326094,0.0005831748,0.0002322898,0.0009679769,0.0001012533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001093908,"about_ca_system_score_gemma":0.0009068729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002153576,"about_ca_topic_score_gemma":0.005175974,"domain_scores_codex":[0.9993495,0.0002178417,0.00005728369,0.00008621274,0.0001462511,0.0001428515],"domain_scores_gemma":[0.9972606,0.00114768,0.0009099928,0.0001093065,0.000190445,0.0003819377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02393229,0.001401643,0.7524954,0.0002359389,0.001352965,0.0002874812,0.0003087853,0.001785066,0.005762807,0.0005060271,0.001798934,0.2101327],"study_design_scores_gemma":[0.0002382657,0.005804348,0.9880915,0.00005067318,0.0006436378,0.0003531995,0.0001324546,0.0009553088,0.001207635,0.000381117,0.002127881,0.00001387046],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929286,0.004992396,0.0001294958,0.0003326539,0.00004198706,0.0000110706,0.0001268713,0.00000712111,0.001429733],"genre_scores_gemma":[0.998969,0.000427782,0.00004599594,0.0001191679,0.00003711302,0.000004149691,0.0001444258,0.000003141235,0.0002492647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002153576,"threshold_uncertainty_score":0.007936895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136359745647564,"score_gpt":0.4247044064405806,"score_spread":0.3110684318758242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}