{"id":"W2573089847","doi":"10.1016/j.clgc.2017.01.005","title":"Discontinuing VEGF-targeted Therapy for Progression Versus Toxicity Affects Outcomes of Second-line Therapies in Metastatic Renal Cell Carcinoma","year":2017,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Queen Elizabeth II Health Sciences Centre; University of Alberta; University of British Columbia; BC Cancer Agency; Dalhousie University","funders":"National Cancer Institute","keywords":"Medicine; Renal cell carcinoma; Oncology; Toxicity; VEGF receptors; Internal medicine; Targeted therapy; Second-line therapy; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006045842,0.0003399309,0.001102907,0.0001053028,0.0001483029,0.0000308773,0.0003002141,0.0001475992,0.0001419801],"category_scores_gemma":[0.0002358903,0.0002330613,0.000551932,0.00007133629,0.0002693507,0.0001475517,0.0001149544,0.0003197456,0.000003130785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001287907,"about_ca_system_score_gemma":0.0002549912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006876545,"about_ca_topic_score_gemma":0.0001786206,"domain_scores_codex":[0.9977351,0.0001873629,0.0007805831,0.0005539088,0.0003115043,0.00043152],"domain_scores_gemma":[0.9973544,0.0008123672,0.000660364,0.0008438157,0.0001301723,0.000198845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01591654,0.001992561,0.8867404,0.0003585881,0.0004659999,0.0002961483,0.000428391,0.00001022095,0.03211883,0.000004572861,0.0003480892,0.06131965],"study_design_scores_gemma":[0.01954814,0.006620562,0.8600274,0.0001637883,0.0002010689,0.000003277634,0.0001056086,0.000103002,0.1125177,0.00005264262,0.0004388938,0.0002178453],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891977,0.006861031,0.00001449823,0.0007649355,0.0008815595,0.001808819,0.00006306502,0.00002610189,0.0003822391],"genre_scores_gemma":[0.9955446,0.0004616957,0.002177854,0.0001069667,0.0004173593,0.0003981659,0.0000311756,0.00005375511,0.0008084322],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0803989,"threshold_uncertainty_score":0.9503964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1136359745647564,"score_gpt":0.4247044064405806,"score_spread":0.3110684318758242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}