{"id":"W2573216598","doi":"10.1007/s40265-017-0690-8","title":"Chimeric Antigen Receptor (CAR) T Cells: Lessons Learned from Targeting of CD19 in B-Cell Malignancies","year":2017,"lang":"en","type":"review","venue":"Drugs","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Cancer Institute","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; CD19; Cell therapy; Immunology; Lymphoma; Chronic lymphocytic leukemia; B cell; Cancer research; Clinical trial; T cell; Leukemia; Antigen; Oncology; Stem cell; Internal medicine; Immune system; Biology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006753422,0.0006770713,0.00104412,0.001128722,0.0001965421,0.0009474921,0.0008118168,0.001187589,0.002429805],"category_scores_gemma":[0.0007195864,0.0002035065,0.0003750196,0.001096592,0.0005781794,0.001468366,0.0006301624,0.002566756,0.001257161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006392076,"about_ca_system_score_gemma":0.0009962778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008071955,"about_ca_topic_score_gemma":0.001818654,"domain_scores_codex":[0.9998679,0.00002100445,0.00001371412,0.000026276,0.00005006999,0.00002098885],"domain_scores_gemma":[0.9996943,0.0001739737,0.00002945308,0.000007419908,0.00006481652,0.00003003304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001138207,0.00008628741,0.0001276646,0.01039937,0.00007035257,0.0001812954,0.0000445797,0.0004709475,0.002849967,0.006724565,0.03833983,0.9405914],"study_design_scores_gemma":[0.0000326363,0.00009869643,0.0002785145,0.001465666,0.00007469326,0.0006952723,0.00003488472,0.000113769,0.0007742533,0.00205437,0.9943649,0.00001237818],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001212907,0.9982774,0.0001939235,0.0005125219,0.0002218438,0.000003120784,0.00001538158,0.000007736282,0.0006467304],"genre_scores_gemma":[0.0008958114,0.997783,0.0002027209,0.0003913508,0.0002133652,0.000005185359,0.00002411213,0.000001737781,0.0004826681],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002429805,"threshold_uncertainty_score":0.008128524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1522524835546747,"score_gpt":0.4061013806561805,"score_spread":0.2538488971015058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}