{"id":"W2573284551","doi":"10.1073/pnas.1612901114","title":"Biosynthesis of the microtubule-destabilizing diterpene pseudolaric acid B from golden larch involves an unusual diterpene synthase","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Diterpene; Biosynthesis; Biology; Terpene; Biochemistry; Stereochemistry; Enzyme; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009995596,0.0001582238,0.0002019373,0.00005165528,0.0004737703,0.00006617407,0.002533216,0.0001988905,0.000008100145],"category_scores_gemma":[0.001442744,0.00009546607,0.0001540028,0.0001685349,0.0015741,0.00006927784,0.0006103261,0.0001318583,5.449669e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001315775,"about_ca_system_score_gemma":0.00006965238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004032714,"about_ca_topic_score_gemma":0.000001329955,"domain_scores_codex":[0.9983866,0.0000221521,0.0003425476,0.0004042241,0.0006535756,0.000190965],"domain_scores_gemma":[0.9988236,0.00008337998,0.0007678291,0.00007279599,0.0002018801,0.00005051422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005067663,0.00008520279,0.0195208,0.00005071751,0.00003469345,1.436086e-8,0.00005217008,0.000002075782,0.9795467,0.0001564399,0.000113258,0.0003872318],"study_design_scores_gemma":[0.0001161204,0.00004565966,0.07108817,0.0001651563,0.00003041073,0.000007221904,0.0001177076,0.00006808057,0.9268923,0.001237825,0.0001151714,0.000116151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974203,0.0002434715,6.559051e-7,0.0013012,0.00002967187,0.0001372704,0.0002732171,0.000005146423,0.0005890877],"genre_scores_gemma":[0.9988202,0.00006686888,0.0007684954,0.0001029963,0.0001646036,0.000006629667,0.000001660655,0.000008044492,0.0000605127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05265439,"threshold_uncertainty_score":0.5799836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04226494111980759,"score_gpt":0.2996339368544963,"score_spread":0.2573689957346887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}