{"id":"W2573715876","doi":"10.1182/blood.v126.23.3675.3675","title":"Generation of Synthetic T-ALL By De Novo Transformation of Human Cord Blood Progenitors with a 4-Oncogene Cocktail","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Biology; Progenitor cell; Haematopoiesis; Population; CD34; Stem cell; Viral vector; Cord blood; Transduction (biophysics); Immunology; Virology; Cancer research; Molecular biology; Cell biology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00031959,0.0003767618,0.0002393003,0.0002865982,0.0002023138,0.0005206418,0.0004212037,0.0003109557,0.00180327],"category_scores_gemma":[0.0001551606,0.0001892955,0.0002881355,0.0002772985,0.0001481823,0.0001444921,0.0003790233,0.000798696,0.001008022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003349923,"about_ca_system_score_gemma":0.000307189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005053942,"about_ca_topic_score_gemma":0.0005590754,"domain_scores_codex":[0.9997972,0.00003091395,0.00003363964,0.00004428337,0.00006610624,0.00002795508],"domain_scores_gemma":[0.9998804,0.00001762006,0.00003011918,0.00002599865,0.00001825323,0.00002750581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009556003,0.00004424291,0.0002228169,0.0000400479,0.000008679239,0.00007601321,0.00002802005,0.0002218479,0.9953366,0.0003855792,0.0001624369,0.003378275],"study_design_scores_gemma":[0.00002857145,0.0002145924,0.0006141461,0.0000071663,0.00002312873,0.0003780622,0.00001195161,0.001344676,0.9868378,0.00005762203,0.0104782,0.000003960763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9277254,0.001522858,0.05857253,0.0002102073,0.0001348632,0.0008117823,0.003318768,0.0006757044,0.007027873],"genre_scores_gemma":[0.9425873,0.001178932,0.03963089,0.00009032746,0.00002373285,0.0003815416,0.005524375,0.000164576,0.01041841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00180327,"threshold_uncertainty_score":0.006032586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04791583260110367,"score_gpt":0.3043219001626635,"score_spread":0.2564060675615598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}