{"id":"W2574064466","doi":"10.1093/hmg/ddx021","title":"A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Biology; Humanized mouse; Mutant; Allele; Huntingtin Protein; Huntington's disease; Genetics; Mutation; Disease; Gene; In vivo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007365998,0.00132464,0.0007025914,0.001357166,0.0006195511,0.0005725779,0.001095569,0.001543385,0.007343831],"category_scores_gemma":[0.0002538718,0.0005684968,0.0008138446,0.0004685819,0.0005856557,0.0008211628,0.0004910298,0.00231799,0.002369806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005872757,"about_ca_system_score_gemma":0.0007229965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006078983,"about_ca_topic_score_gemma":0.001541576,"domain_scores_codex":[0.9994484,0.00006455187,0.00007065135,0.0001649513,0.0001557732,0.00009574374],"domain_scores_gemma":[0.9996384,0.0000379645,0.00007954821,0.00005502813,0.00005595059,0.0001328959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007128554,0.0007601004,0.000275732,0.0001265516,0.00003499009,0.0002773405,0.00006087582,0.0002311376,0.9869587,0.002045386,0.001319609,0.00719676],"study_design_scores_gemma":[0.001168738,0.007125399,0.00484438,0.0001466855,0.0002566483,0.003822931,0.00008073311,0.002980208,0.8993093,0.001202263,0.0789889,0.00007372668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8194085,0.005962415,0.1244523,0.002492161,0.001608136,0.003811875,0.01851822,0.003877712,0.0198686],"genre_scores_gemma":[0.741893,0.007025796,0.1376028,0.001417197,0.0003478928,0.008378351,0.02131194,0.0006156302,0.08140736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007343831,"threshold_uncertainty_score":0.02456754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294152717704731,"score_gpt":0.3548365464336763,"score_spread":0.2254212746632032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}