{"id":"W2574064466","doi":"10.1093/hmg/ddx021","title":"A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles","year":2017,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Huntingtin; Biology; Humanized mouse; Mutant; Allele; Huntingtin Protein; Huntington's disease; Genetics; Mutation; Disease; Gene; In vivo","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003244339,0.0003334741,0.0004414878,0.00009457004,0.0006603744,0.0001000827,0.001058126,0.00008700851,0.00000994581],"category_scores_gemma":[0.001197343,0.0003485147,0.0002600927,0.00004942494,0.0004280815,0.00005105358,0.0004478114,0.0001267592,0.00000165352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001945706,"about_ca_system_score_gemma":0.000283343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002242248,"about_ca_topic_score_gemma":0.000007201811,"domain_scores_codex":[0.9971722,0.00009928799,0.0009919816,0.0007268933,0.0005623912,0.0004472062],"domain_scores_gemma":[0.9973195,0.0001266511,0.001005865,0.001055577,0.0003168379,0.0001755635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009185151,0.0005284653,0.0006446278,0.0001461331,0.00003166594,7.222551e-7,0.0003739546,0.005581987,0.9906993,0.001360851,0.000005292957,0.0005351653],"study_design_scores_gemma":[0.001341226,0.0001005714,0.002509695,0.00004235104,0.0001160138,1.287795e-7,0.00002684243,0.02092083,0.9737662,0.0007462539,0.00009634325,0.0003335276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9444249,0.00007740458,0.05433659,0.00003778884,0.00007071965,0.0007987407,0.0001296706,0.00003309761,0.00009111239],"genre_scores_gemma":[0.9370546,0.00002522171,0.06240576,0.0001869763,0.00003819844,0.00006906606,0.00001772368,0.00009110111,0.0001113145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01693307,"threshold_uncertainty_score":0.9998967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294152717704731,"score_gpt":0.3548365464336763,"score_spread":0.2254212746632032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}