{"id":"W2574134106","doi":"10.1182/blood.v112.11.950.950","title":"QLT0267, a Small Molecule Inhibitor of ILK and FLT3 Is Cytotoxic to Acute Myeloid Leukemia (AML) ‘Stem Cells’ Detected in Immunodeficient Mice.","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Integrin-linked kinase; Cancer research; Protein kinase B; Fms-Like Tyrosine Kinase 3; CD34; Myeloid leukemia; Leukemia; Biology; Myeloid; Kinase; CD38; Cytotoxic T cell; Stem cell; Molecular biology; Chemistry; Signal transduction; Immunology; In vitro; Cell biology; Protein kinase A; Biochemistry; Mutation; Cyclin-dependent kinase 2","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002052281,0.0007017092,0.0004479158,0.0005919842,0.0001612495,0.000286425,0.0003094276,0.0005227737,0.002716008],"category_scores_gemma":[0.0001379755,0.0002933689,0.0003434999,0.0003010733,0.0003433113,0.0002365509,0.0001936025,0.001060276,0.0007071141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002696205,"about_ca_system_score_gemma":0.0002471565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005987227,"about_ca_topic_score_gemma":0.0009850435,"domain_scores_codex":[0.9996761,0.00005450279,0.00002926433,0.00004248918,0.0001010681,0.00009654491],"domain_scores_gemma":[0.99976,0.00005170003,0.00006084785,0.00001885054,0.00001816165,0.00009044317],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005592003,0.0002336689,0.0001450799,0.00003866151,0.0000114046,0.00006141564,0.00001311201,0.0001011273,0.9966729,0.000104921,0.0001862079,0.001872254],"study_design_scores_gemma":[0.0002799546,0.003250801,0.004824718,0.000009785141,0.00002696163,0.0003916022,0.0000160447,0.001604804,0.9871265,0.0000456253,0.002416259,0.000006998062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909347,0.001443632,0.001884883,0.0002429915,0.00008394014,0.0001289886,0.001202586,0.0003899395,0.003688164],"genre_scores_gemma":[0.9870335,0.0009277707,0.001953436,0.0002086184,0.00002746374,0.0001539677,0.004330101,0.00005025068,0.005314849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002716008,"threshold_uncertainty_score":0.009085953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01616144116951526,"score_gpt":0.2404574319555943,"score_spread":0.2242959907860791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}