{"id":"W2574286987","doi":"10.1016/j.ebiom.2017.01.012","title":"Downregulation of PDZ Domain Containing 1 (PDZK1) is a Poor Prognostic Marker for Clear Cell Renal Cell Carcinoma","year":2017,"lang":"en","type":"letter","venue":"EBioMedicine","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Clear cell renal cell carcinoma; PDZ domain; Renal cell carcinoma; Biomarker; Clear cell carcinoma; Oncology; Medicine; Disease; Clear cell; Internal medicine; Cancer; Kidney cancer; Bioinformatics; Cancer research; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006876844,0.0008942789,0.001915054,0.0007412704,0.000212741,0.00004091347,0.0004303243,0.001105367,0.0004780919],"category_scores_gemma":[0.0001528864,0.0007026015,0.0006352744,0.0002158405,0.0005008479,0.00007649254,0.0001293709,0.001100896,0.00006561146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004411104,"about_ca_system_score_gemma":0.00051354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002356512,"about_ca_topic_score_gemma":0.000004183083,"domain_scores_codex":[0.9953214,0.0001346608,0.001219869,0.001131226,0.001238402,0.0009544673],"domain_scores_gemma":[0.9956759,0.0005314119,0.001392566,0.001545243,0.0005455171,0.0003093295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00284344,0.0002999793,0.005307116,0.005676749,0.0003589215,0.002792635,0.0009012938,4.307572e-7,0.05426404,0.000003608776,0.9258032,0.001748534],"study_design_scores_gemma":[0.02214397,0.01478816,0.06287449,0.002666762,0.004260634,0.0005507234,0.0002532392,0.0002749332,0.03619915,0.0002153491,0.8546751,0.001097545],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5452814,0.005198016,0.0008304962,0.4141198,0.001306879,0.009570203,0.0008543762,0.0001743406,0.02266447],"genre_scores_gemma":[0.8889939,0.00003140635,0.004937373,0.06607146,0.00720994,0.0003981124,0.004474815,0.0003020964,0.02758095],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3480483,"threshold_uncertainty_score":0.9995425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02428458582977538,"score_gpt":0.2622506472989068,"score_spread":0.2379660614691315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}