{"id":"W2574380159","doi":"10.1182/blood.v126.23.329.329","title":"Tosedostat Plus Low Dose Cytarabine Induces a High Rate of Responses That Can be Predicted By Genetic Profiling in Elderly AML","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cytarabine; Medicine; Internal medicine; Myeloid leukemia; Chemotherapy; Prospective cohort study; Gastroenterology; Induction chemotherapy; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003454177,0.000133948,0.0002919908,0.0001774026,0.00009808228,0.0001673838,0.00006716964,0.0001391508,0.0005719632],"category_scores_gemma":[0.0004585493,0.00008650294,0.00017635,0.0001364224,0.0001199716,0.00007637168,0.0001132685,0.0001816939,0.0001405495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060944,"about_ca_system_score_gemma":0.0001007603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001693156,"about_ca_topic_score_gemma":0.000161687,"domain_scores_codex":[0.9998602,0.0000479998,0.00001168907,0.00003073569,0.00002725066,0.00002214852],"domain_scores_gemma":[0.9997907,0.00007265478,0.00004761042,0.00002796716,0.00001709277,0.000044075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.0238216,0.00131572,0.3360629,0.0001051217,0.0001750706,0.001047243,0.0002877208,0.001488482,0.5766789,0.00009867537,0.0004013935,0.05851716],"study_design_scores_gemma":[0.001296874,0.03371566,0.8666753,0.00001374703,0.0002225677,0.003476966,0.0001322139,0.002740226,0.08882845,0.0001010904,0.002780618,0.00001628155],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996467,0.0000864317,0.000117402,0.000004385954,0.000001511057,0.000008395687,0.00003395234,0.000004496236,0.00009677473],"genre_scores_gemma":[0.999544,0.00004527669,0.0001339013,0.00001749573,0.000003618359,0.00001006707,0.0001306768,0.000001885243,0.0001131842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005719632,"threshold_uncertainty_score":0.001913428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299385948849215,"score_gpt":0.2679208205632074,"score_spread":0.2379822256782859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}