{"id":"W2574380159","doi":"10.1182/blood.v126.23.329.329","title":"Tosedostat Plus Low Dose Cytarabine Induces a High Rate of Responses That Can be Predicted By Genetic Profiling in Elderly AML","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Cytarabine; Medicine; Internal medicine; Myeloid leukemia; Chemotherapy; Prospective cohort study; Gastroenterology; Induction chemotherapy; Oncology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002803121,0.0001644604,0.0004024048,0.0002708539,0.00002508803,0.00001602169,0.00008257948,0.0001058962,0.00005501375],"category_scores_gemma":[0.0002891077,0.0001408818,0.00007054555,0.0004399628,0.00008499673,0.00005969216,0.00003144658,0.0001756791,0.00000279144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005048121,"about_ca_system_score_gemma":0.0003967769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007502545,"about_ca_topic_score_gemma":0.0001792419,"domain_scores_codex":[0.9986534,0.0001651931,0.0003658041,0.0002699828,0.0002965831,0.0002490858],"domain_scores_gemma":[0.9991553,0.00007298989,0.0001400817,0.0002668166,0.0001409858,0.0002237783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001738694,0.002001038,0.035197,0.0002611317,0.0003196879,0.0006284059,0.002095818,0.00008352109,0.9547257,0.00002188816,0.0020156,0.0009114616],"study_design_scores_gemma":[0.01767883,0.001192096,0.02592311,0.0007435575,0.0003224438,0.00004708156,0.001046839,0.0003367701,0.9522729,0.00008214051,0.0001208055,0.0002334614],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974864,0.0002222143,0.0000191824,0.001471385,0.00002067492,0.0003173501,0.000301546,0.00005441873,0.0001068844],"genre_scores_gemma":[0.9978275,0.00003990986,0.0006751576,0.0004407799,0.00005739392,0.00003237138,0.0002889626,0.0000208505,0.0006170918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01594014,"threshold_uncertainty_score":0.5744994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299385948849215,"score_gpt":0.2679208205632074,"score_spread":0.2379822256782859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}