{"id":"W2574539339","doi":"10.1038/ncomms14132","title":"Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Light Source","keywords":"Farnesyl pyrophosphate; ATP synthase; Pyrophosphate; Chemistry; Farnesyl diphosphate synthase; Allosteric regulation; Biochemistry; Enzyme; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0003642248,0.0002071038,0.0002373457,0.0000999674,0.002851743,0.000465269,0.003241347,0.0002745316,0.0001291264],"category_scores_gemma":[0.0009321375,0.0001890861,0.00010903,0.000209214,0.0004308939,0.0004021642,0.0009900458,0.00153604,0.0002130182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008464276,"about_ca_system_score_gemma":0.00003704692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001101888,"about_ca_topic_score_gemma":0.0001233354,"domain_scores_codex":[0.9983204,0.0001812492,0.000301011,0.0003991982,0.0003973611,0.0004007668],"domain_scores_gemma":[0.9943211,0.0001064046,0.0002452739,0.004779857,0.0003960736,0.0001513013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007035014,0.001107275,0.007190022,0.00009063757,0.0001061236,0.000009662567,0.0007376759,3.976561e-7,0.6245826,0.001979815,0.3218973,0.04222817],"study_design_scores_gemma":[0.001005403,0.0001454554,0.04165799,0.000250877,0.00006534136,0.00001299919,0.00008053134,0.0002285753,0.1508062,0.0003303791,0.804871,0.0005452887],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7046899,0.0356914,0.00001534465,0.2248068,0.0008132482,0.001436169,0.0004784663,0.0003961001,0.03167253],"genre_scores_gemma":[0.9930097,0.0005036241,0.00050702,0.001220196,0.00008972473,0.00004697181,0.0001160844,0.00004561692,0.004461054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4829736,"threshold_uncertainty_score":0.9984464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174362893638268,"score_gpt":0.3796143858264702,"score_spread":0.3378707568900876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}