{"id":"W2574539339","doi":"10.1038/ncomms14132","title":"Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product","year":2017,"lang":"en","type":"article","venue":"Nature Communications","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Light Source","keywords":"Farnesyl pyrophosphate; ATP synthase; Pyrophosphate; Chemistry; Farnesyl diphosphate synthase; Allosteric regulation; Biochemistry; Enzyme; Pharmacology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003137041,0.000217628,0.0003291847,0.0001435989,0.0001204978,0.0004236804,0.0002832602,0.0002944309,0.002196121],"category_scores_gemma":[0.0003552565,0.0002134603,0.00020544,0.0001372473,0.0003987227,0.0001147413,0.0001576254,0.0003889539,0.0006093714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003243032,"about_ca_system_score_gemma":0.0002070906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006142541,"about_ca_topic_score_gemma":0.0005472552,"domain_scores_codex":[0.999728,0.0000685666,0.00002796701,0.00007597032,0.00005810443,0.00004122139],"domain_scores_gemma":[0.999811,0.00008694032,0.00003305703,0.00003357018,0.000008330307,0.0000271088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003523807,0.00005072397,0.0003672873,0.00002620603,0.000009959911,0.00008825014,0.00001854459,0.0001095668,0.9976526,0.0001843907,0.00007656551,0.001063536],"study_design_scores_gemma":[0.00004937858,0.0002693555,0.002157553,0.000004898378,0.00001015702,0.0004505028,0.0000187053,0.00183946,0.9934281,0.0001293162,0.001634067,0.000008450057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953325,0.001076466,0.002128022,0.0001572186,0.00005198006,0.00001225693,0.0001805969,0.0001314566,0.0009294565],"genre_scores_gemma":[0.9979656,0.000196818,0.0006940233,0.0000306514,0.000009480565,0.00001083176,0.0002813273,0.00001793405,0.0007932377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002196121,"threshold_uncertainty_score":0.007346809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04174362893638268,"score_gpt":0.3796143858264702,"score_spread":0.3378707568900876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}