{"id":"W2574727666","doi":"10.1002/cam4.961","title":"Nonpromoter methylation of the CDKN2A gene with active transcription is associated with improved locoregional control in laryngeal squamous cell carcinoma","year":2017,"lang":"en","type":"article","venue":"Cancer Medicine","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"National Institute of Dental and Craniofacial Research; National Cancer Institute; University of Pittsburgh; Vanderbilt University","keywords":"CDKN2A; Cancer research; Methylation; Basal cell; Transcription factor; Oncology; Gene; Carcinoma; Biology; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002680695,0.0001217385,0.0002318645,0.0004199235,0.0002057822,0.0003167913,0.0001325001,0.0001396315,0.0009985109],"category_scores_gemma":[0.000703896,0.0001060072,0.0001886048,0.00030557,0.0002701967,0.0001093611,0.0002262335,0.0001831978,0.000112256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003465198,"about_ca_system_score_gemma":0.0002056106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002601861,"about_ca_topic_score_gemma":0.004501522,"domain_scores_codex":[0.9998688,0.00002581818,0.00001162246,0.0000396286,0.00003295742,0.00002111015],"domain_scores_gemma":[0.9996418,0.00008890368,0.0001428279,0.00004654434,0.00002922192,0.00005071979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004697903,0.0000157836,0.9648596,0.00002096041,0.00005063403,0.0002102919,0.00009333606,0.0001770388,0.02898864,0.00002146128,0.00005538777,0.005037142],"study_design_scores_gemma":[0.000003426996,0.00004204259,0.9969308,0.000001618325,0.00002047916,0.0002787758,0.00003464998,0.0002643487,0.002290509,0.00002401034,0.0001074178,0.000001964279],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.999491,0.0001629886,0.000123259,0.00001074331,9.165503e-7,0.000001816681,0.00007155802,0.000005544559,0.0001321756],"genre_scores_gemma":[0.9997439,0.00004001357,0.00004681514,0.000005300044,0.000001737046,0.000001631012,0.00006041609,0.00000184163,0.00009835028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002601861,"threshold_uncertainty_score":0.005173445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01263339832515411,"score_gpt":0.2502421654542536,"score_spread":0.2376087671290995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}