{"id":"W2574824340","doi":"10.1182/blood.v126.23.4137.4137","title":"Highly Restricted Usage of Immunoglobulin Light Chain IGKV3-20 with Stereotyped Sequence in Primary Cold-Agglutinin Disease (CAD)","year":2015,"lang":"en","type":"article","venue":"Blood","topic":"Blood groups and transfusion","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"","keywords":"Immunology; Antibody; Immunoglobulin light chain; Bone marrow; Biology; Cold agglutinin disease; Immunoglobulin gene; Immunoglobulin M; Autoimmune hemolytic anemia; Immunoglobulin G; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002358969,0.0002122281,0.0004486106,0.0001677639,0.0000285863,0.00001040397,0.0001520039,0.0001109412,0.00001559399],"category_scores_gemma":[0.00006396027,0.0001639465,0.00006119472,0.0006255661,0.00008498945,0.0001018174,0.00004860016,0.0002573786,0.0000142091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005117701,"about_ca_system_score_gemma":0.0005370214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002409824,"about_ca_topic_score_gemma":0.00006800931,"domain_scores_codex":[0.9983574,0.00009171018,0.0004163512,0.0003508665,0.0004701466,0.0003135129],"domain_scores_gemma":[0.9988527,0.00004440438,0.0001285622,0.0004884159,0.0001403228,0.000345643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00933637,0.008643827,0.6273338,0.00103359,0.0003765997,0.003930965,0.00158365,0.00002475395,0.3446274,0.0008083959,0.000430198,0.001870454],"study_design_scores_gemma":[0.03778203,0.002877752,0.9102452,0.001389157,0.0008731475,0.0001123395,0.0001421716,0.00008134067,0.04348967,0.0000952616,0.002422186,0.0004897176],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936445,0.001884669,0.00002820043,0.0009292487,0.00006243424,0.0006888177,0.00005923683,0.0000709344,0.002631912],"genre_scores_gemma":[0.99796,0.0001089659,0.001067708,0.0002186109,0.00007668754,0.00003150807,0.0000855531,0.00003429945,0.0004167025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3011378,"threshold_uncertainty_score":0.6685544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890718711817125,"score_gpt":0.2336955911966431,"score_spread":0.2147884040784719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}