{"id":"W2574939094","doi":"10.1038/srep40342","title":"CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":285,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"Guangdong Provincial People's Hospital; Natural Science Foundation of Guangdong Province; National Natural Science Foundation of China; National Institutes of Health; National Science Foundation","keywords":"CTGF; Circular RNA; Downregulation and upregulation; Fibrosis; Cardiac fibrosis; Cell biology; microRNA; Reporter gene; Chemistry; Transfection; Gene expression; Cancer research; Gene; Biology; Growth factor; Medicine; Internal medicine; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853386,0.0004246603,0.0004272187,0.0002675917,0.0002539442,0.0004748237,0.0001593326,0.0003341805,0.001365155],"category_scores_gemma":[0.0002534256,0.0002232443,0.0003670791,0.0002367131,0.0003336689,0.0001578499,0.000172472,0.0006193282,0.0005139866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115694,"about_ca_system_score_gemma":0.0003278511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005316173,"about_ca_topic_score_gemma":0.0008789686,"domain_scores_codex":[0.9997491,0.00003438466,0.00003394785,0.00005883103,0.00008830262,0.00003540328],"domain_scores_gemma":[0.9998152,0.00004600848,0.0000587808,0.00001839708,0.00002161905,0.00004013406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001311872,0.00003748635,0.0001830028,0.00006272193,0.000006105412,0.00005531165,0.00002333811,0.00005659126,0.9981521,0.0001045294,0.00009118236,0.001096513],"study_design_scores_gemma":[0.0000333231,0.0004752268,0.004893485,0.00001569445,0.00003465649,0.0003722557,0.00004446529,0.001555239,0.9855823,0.00006903272,0.006910403,0.00001397453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856742,0.00327355,0.004859868,0.0002669011,0.0002108496,0.00009421194,0.001233551,0.0003704414,0.004016467],"genre_scores_gemma":[0.9837802,0.001624909,0.006794011,0.0004041715,0.00004606146,0.0001387164,0.002440121,0.0001279618,0.004643816],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365155,"threshold_uncertainty_score":0.004566908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007799747042081077,"score_gpt":0.2532657163566582,"score_spread":0.2454659693145771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}