{"id":"W2575232561","doi":"10.1126/scitranslmed.aag2196","title":"Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma","year":2017,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":330,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bausch Health (Canada)","funders":"Ben and Catherine Ivy Foundation; National Cancer Institute; National Institute of Neurological Disorders and Stroke; Wellcome; Royal Society; Wellcome Trust","keywords":"Glioma; Cytotoxic T cell; Cancer research; Immunotherapy; Reporter gene; Medicine; Genetic enhancement; Gene; Pet imaging; Pathology; Immunology; Biology; Gene expression; Positron emission tomography; Immune system; Nuclear medicine; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002831832,0.0003611425,0.0002878897,0.0002885613,0.0001059054,0.0002616624,0.0004372852,0.00050405,0.0006222875],"category_scores_gemma":[0.0001625492,0.000159884,0.0001750595,0.000229501,0.0002633114,0.0003016177,0.0001810407,0.0003868151,0.0001944857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005002415,"about_ca_system_score_gemma":0.0004530333,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003874598,"about_ca_topic_score_gemma":0.002152226,"domain_scores_codex":[0.9999068,0.00002170429,0.000003472755,0.00001964437,0.00001714751,0.00003126902],"domain_scores_gemma":[0.9999679,0.000007738844,0.000009170371,0.000002947132,0.000004936294,0.000007310379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854451,0.00005710159,0.0002216716,0.00006726049,0.000009029736,0.000227995,0.00006343759,0.00107073,0.9904566,0.0007769294,0.0002245241,0.006539326],"study_design_scores_gemma":[0.00005132964,0.0006411082,0.00125537,0.000007254122,0.00004094842,0.000710699,0.00004147697,0.009276642,0.9859847,0.0001474064,0.001832553,0.00001053029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9769635,0.001853489,0.01851692,0.000228698,0.00002571182,0.00004981234,0.0001911931,0.0002290765,0.00194154],"genre_scores_gemma":[0.990972,0.0007035066,0.006358196,0.00003451745,0.000009822379,0.00003337837,0.0001511536,0.00003542904,0.001701911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003874598,"threshold_uncertainty_score":0.007704079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04301497310250961,"score_gpt":0.3738410366915573,"score_spread":0.3308260635890477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}