{"id":"W2575280891","doi":"10.1182/blood.v114.22.2462.2462","title":"Systemic Delivery of the Cancer Gene Therapy Biologic, SNS01, Has Significant Anti-Tumoral Activity in a Murine Model of Multiple Myeloma.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biology; Molecular biology; Apoptosis; Transfection; Messenger RNA; Cancer cell; Small interfering RNA; Cancer research; Polyethylenimine; Cell culture; Gene; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009080823,0.0001052635,0.0001919327,0.00002606032,0.00003135603,0.000003601643,0.0002463192,0.00007573866,0.000001581898],"category_scores_gemma":[0.00001423102,0.0000721939,0.00008113839,0.0001093929,0.00007958733,0.000002528186,0.00005029184,0.00005259854,2.84355e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003798223,"about_ca_system_score_gemma":0.00009956915,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001730382,"about_ca_topic_score_gemma":0.00003347777,"domain_scores_codex":[0.9993429,0.00004613424,0.0001896396,0.0002111031,0.00006758995,0.0001425986],"domain_scores_gemma":[0.9994157,0.000007615648,0.0001381701,0.0003680236,0.00004645488,0.00002402631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003735572,0.0004242692,0.0160648,0.000008697406,0.00002092929,2.615811e-7,0.0000239542,0.0008413669,0.9810095,0.0000139598,0.00001907772,0.001535852],"study_design_scores_gemma":[0.001005298,0.00005945962,0.07768087,0.00001154172,0.00001661467,0.000002279431,0.000008934068,0.0006593125,0.9204062,0.00002636905,0.00004369515,0.00007938403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966046,0.002536775,0.0002141017,0.0001038468,0.00002142311,0.0002711344,0.0002193259,0.000004769149,0.00002406178],"genre_scores_gemma":[0.9983287,0.001270208,0.0002180022,0.00006060807,0.00004299818,0.00003856583,0.00001704055,0.000005383219,0.00001844291],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06161607,"threshold_uncertainty_score":0.2943982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586164940164124,"score_gpt":0.2449429003474912,"score_spread":0.21908125094585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}