{"id":"W2575280891","doi":"10.1182/blood.v114.22.2462.2462","title":"Systemic Delivery of the Cancer Gene Therapy Biologic, SNS01, Has Significant Anti-Tumoral Activity in a Murine Model of Multiple Myeloma.","year":2009,"lang":"en","type":"article","venue":"Blood","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Biology; Molecular biology; Apoptosis; Transfection; Messenger RNA; Cancer cell; Small interfering RNA; Cancer research; Polyethylenimine; Cell culture; Gene; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002907449,0.0007754232,0.000443479,0.0006530365,0.0002417112,0.0003686163,0.0003543622,0.000838656,0.002163324],"category_scores_gemma":[0.00009894654,0.0002387112,0.0005453341,0.0003881163,0.0003544614,0.0003287858,0.0001469937,0.001473194,0.0007203247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005573659,"about_ca_system_score_gemma":0.0005650551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001571901,"about_ca_topic_score_gemma":0.002180266,"domain_scores_codex":[0.9997615,0.00002827232,0.00001279212,0.00006532453,0.00007476207,0.00005745342],"domain_scores_gemma":[0.9998167,0.00002451843,0.00005500226,0.00001726503,0.00001905543,0.00006755877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007026107,0.0004369123,0.0001126845,0.00006916995,0.00001758805,0.00005954827,0.00001737168,0.0002614124,0.9943581,0.0001985575,0.0004063109,0.003359806],"study_design_scores_gemma":[0.0001435794,0.004546505,0.001616662,0.00001383004,0.0000490872,0.0002079941,0.00002126294,0.001743702,0.986775,0.0000590737,0.00481426,0.00000904338],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9716879,0.004652939,0.01028425,0.000848045,0.0005016956,0.0004003565,0.003348585,0.0008024682,0.007473743],"genre_scores_gemma":[0.9593569,0.003618778,0.01108139,0.0002680065,0.00007902305,0.000383525,0.003505236,0.0001092403,0.02159797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002163324,"threshold_uncertainty_score":0.007237017,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586164940164124,"score_gpt":0.2449429003474912,"score_spread":0.21908125094585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}