{"id":"W2575321765","doi":"10.1038/leu.2017.17","title":"The clonal origins of leukemic progression of myelodysplasia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Biology; Exome sequencing; Genetics; Mutation; Exome; Myeloid leukemia; Somatic evolution in cancer; Myelodysplastic syndromes; Somatic cell; Germline mutation; DNA methylation; Gene; Myeloid; Leukemia; Cancer research; Immunology; Bone marrow; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006155719,0.000170758,0.0001322211,0.0009281832,0.0003500299,0.0007119481,0.0002969039,0.0003383206,0.001503222],"category_scores_gemma":[0.0010506,0.0001505845,0.0001066427,0.0003170907,0.0003241283,0.000600367,0.0005224163,0.0005061974,0.0002723882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003772263,"about_ca_system_score_gemma":0.0003655034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005029639,"about_ca_topic_score_gemma":0.0007759339,"domain_scores_codex":[0.9997844,0.00006622649,0.00001774313,0.00002585147,0.00006677597,0.00003899839],"domain_scores_gemma":[0.9994679,0.0001833708,0.0001160018,0.00007344193,0.0001012188,0.00005798327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008270309,0.0001808198,0.1084756,0.0002682898,0.00005876,0.00435642,0.001232847,0.001154022,0.6549898,0.07217967,0.001667697,0.154609],"study_design_scores_gemma":[0.0002108672,0.001308965,0.4033498,0.0002390731,0.0002590732,0.03241273,0.002128331,0.008266577,0.4386796,0.02237618,0.09070947,0.00005931474],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9732023,0.01335424,0.002835965,0.0004843205,0.00004171022,0.00004422391,0.0001411589,0.00005622721,0.009839718],"genre_scores_gemma":[0.9938174,0.00336088,0.0009050724,0.0000838962,0.00007845749,0.00001645715,0.0001227936,0.000009974504,0.001605008],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503222,"threshold_uncertainty_score":0.005028784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382896740614994,"score_gpt":0.3466196165419312,"score_spread":0.3227906491357813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}