{"id":"W2575321765","doi":"10.1038/leu.2017.17","title":"The clonal origins of leukemic progression of myelodysplasia","year":2017,"lang":"en","type":"article","venue":"Leukemia","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Biology; Exome sequencing; Genetics; Mutation; Exome; Myeloid leukemia; Somatic evolution in cancer; Myelodysplastic syndromes; Somatic cell; Germline mutation; DNA methylation; Gene; Myeloid; Leukemia; Cancer research; Immunology; Bone marrow; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006515399,0.0001829975,0.0004249494,0.0000917509,0.0004470236,0.00003931899,0.0008084042,0.0001826483,0.00006494937],"category_scores_gemma":[0.0007525092,0.0001125715,0.0001740708,0.0001227752,0.0009877918,0.0001297277,0.0003102967,0.0005338251,0.00005140126],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00162953,"about_ca_system_score_gemma":0.002347337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004585772,"about_ca_topic_score_gemma":0.00002901873,"domain_scores_codex":[0.9979794,0.00005700358,0.0004829219,0.0002777693,0.0007661189,0.0004367626],"domain_scores_gemma":[0.9972644,0.0002373619,0.0004921017,0.001521351,0.0003167988,0.0001679886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.004082254,0.0002289535,0.1696913,0.001008529,0.0005951176,0.0002784655,0.0007544914,0.00002415105,0.5035532,0.04248707,0.02724268,0.2500537],"study_design_scores_gemma":[0.007389062,0.001163369,0.4792942,0.0009935042,0.0002008157,0.0002805891,0.0002475092,0.003265116,0.388513,0.001122219,0.1171923,0.0003383566],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820157,0.0003512433,0.00004578955,0.001234388,0.0002173027,0.0004988052,0.00001536886,0.00003237032,0.01558901],"genre_scores_gemma":[0.9951327,0.0003474866,0.001244449,0.00004982105,0.0002469387,0.00002948147,0.00001304408,0.0000342091,0.002901841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3096028,"threshold_uncertainty_score":0.4590532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02382896740614994,"score_gpt":0.3466196165419312,"score_spread":0.3227906491357813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}