{"id":"W2575503691","doi":"10.1128/jvi.02414-16","title":"Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Biology; Herpes simplex virus; Stimulator of interferon genes; Interferon; DNA virus; Interferon type I; Innate immune system; Virus; DNA; RIG-I; Virology; Viral replication; Cell biology; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009915129,0.0003223412,0.0006598114,0.0002077703,0.001025722,0.0000991137,0.0009357257,0.0005070962,0.0005187046],"category_scores_gemma":[0.001763169,0.0002091768,0.0002824008,0.00006650304,0.0007832008,0.0002944776,0.0002189006,0.0009120926,0.0006204653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006053411,"about_ca_system_score_gemma":0.0001743547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001148776,"about_ca_topic_score_gemma":0.0001112355,"domain_scores_codex":[0.9972771,0.0008945262,0.0008407115,0.0002508046,0.00008936959,0.0006474328],"domain_scores_gemma":[0.9970253,0.0005186667,0.0014926,0.000579373,0.0003304669,0.0000535876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001940359,0.0001244949,0.00007442224,0.00001127172,0.0003228263,0.0001091802,0.0005022177,0.000002698006,0.9800839,0.00009589539,0.0008226309,0.01591008],"study_design_scores_gemma":[0.002004332,0.001529956,0.01228678,0.00009615662,0.0000719984,0.001932782,0.0001974581,0.0000486462,0.8282718,0.0001362058,0.153193,0.0002309051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903021,0.003240894,0.0001749636,0.003987476,0.001421614,0.0002782598,0.00002284837,0.00003427615,0.0005374945],"genre_scores_gemma":[0.9975429,0.0001853456,0.00004015759,0.00082691,0.0002452293,0.000004490542,0.00000903377,0.00003717495,0.001108766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1523703,"threshold_uncertainty_score":0.8529981,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907419750152635,"score_gpt":0.2624324601248667,"score_spread":0.2433582626233403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}