{"id":"W2575503691","doi":"10.1128/jvi.02414-16","title":"Herpes Simplex Virus 1 Abrogates the cGAS/STING-Mediated Cytosolic DNA-Sensing Pathway via Its Virion Host Shutoff Protein, UL41","year":2017,"lang":"en","type":"article","venue":"Journal of Virology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":171,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Priority Academic Program Development of Jiangsu Higher Education Institutions; National Natural Science Foundation of China","keywords":"Biology; Herpes simplex virus; Stimulator of interferon genes; Interferon; DNA virus; Interferon type I; Innate immune system; Virus; DNA; RIG-I; Virology; Viral replication; Cell biology; Gene; Immune system; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460353,0.0005361093,0.0003127177,0.0002467927,0.0001634038,0.0003703575,0.0003014989,0.0002602539,0.0009543929],"category_scores_gemma":[0.0001062589,0.0001494805,0.0002994236,0.0001845548,0.0003034646,0.000276312,0.0002355498,0.0005925708,0.00028539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003561713,"about_ca_system_score_gemma":0.0002473817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000435977,"about_ca_topic_score_gemma":0.0004003246,"domain_scores_codex":[0.9997926,0.00003735916,0.00002903425,0.00003645338,0.00004949529,0.00005503494],"domain_scores_gemma":[0.9998899,0.00002194594,0.00003787646,0.00001586913,0.000007662381,0.00002679627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007816239,0.00003197415,0.00004216557,0.0000337203,0.000003202403,0.00002098873,0.00001025396,0.00004343564,0.9991749,0.000113378,0.00002320778,0.0004245701],"study_design_scores_gemma":[0.00001040997,0.000217341,0.0007340763,0.000004267823,0.000009303433,0.00007456519,0.0000142598,0.0007822186,0.9970118,0.00002653721,0.001112103,0.000003192223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955133,0.001632041,0.001600647,0.00006661521,0.00004843389,0.00002393701,0.0003246745,0.0001128817,0.000677555],"genre_scores_gemma":[0.9961874,0.0005868658,0.001282268,0.00002420379,0.00000982847,0.00003510077,0.0004847924,0.00001983729,0.00136972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009543929,"threshold_uncertainty_score":0.003192723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01907419750152635,"score_gpt":0.2624324601248667,"score_spread":0.2433582626233403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}