{"id":"W2575626416","doi":"10.1182/blood.v120.21.2391.2391","title":"Epigenetic Therapy Inhibits NUP98-HOXA9-Mediated Myeloid Disease – Decitabine and Valproic Acid Work Synergistically to Rescue Normal Hematopoiesis in Transgenic Zebrafish.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atlantic Cancer Research Institute; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"Biology; Cancer research; Myeloid leukemia; Decitabine; Zebrafish; Myeloid; Haematopoiesis; GATA1; Leukemia; Immunology; Stem cell; DNA methylation; Cell biology; Genetics; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000146504,0.0004014701,0.0003325932,0.0003523437,0.0001678554,0.0002195304,0.0002982461,0.0003968242,0.002030841],"category_scores_gemma":[0.00009698149,0.0001722723,0.0003091457,0.0001151879,0.0003639233,0.000176439,0.0002437085,0.0006938993,0.0004405569],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003618244,"about_ca_system_score_gemma":0.0003446628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001034633,"about_ca_topic_score_gemma":0.003152444,"domain_scores_codex":[0.999856,0.00001648404,0.00001460597,0.00003440001,0.00004107448,0.00003729232],"domain_scores_gemma":[0.9999126,0.00001022434,0.0000319299,0.000008855687,0.000006255016,0.00003019248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001625587,0.00005589261,0.00006152083,0.00002627082,0.000005964438,0.0000442861,0.000008820257,0.00006838708,0.9976832,0.00009160555,0.0000946591,0.001696907],"study_design_scores_gemma":[0.00006970765,0.0008965448,0.002217661,0.000008615732,0.00002631751,0.0001749069,0.00002389161,0.000747342,0.9923939,0.00004513283,0.003390838,0.000005225307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914194,0.001219682,0.002158425,0.0003073555,0.00009661569,0.0001075827,0.0008542722,0.0003370544,0.003499621],"genre_scores_gemma":[0.9904218,0.0008800642,0.002184726,0.00008117159,0.00001129445,0.000124626,0.0005640844,0.00004703419,0.005685221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002030841,"threshold_uncertainty_score":0.006793857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01664350979140591,"score_gpt":0.2628660821430303,"score_spread":0.2462225723516243,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}