{"id":"W2575649910","doi":"10.1016/j.ibmb.2017.01.007","title":"Mutations of two acidic residues at the cytoplasmic end of segment IIIS6 of an insect sodium channel have distinct effects on pyrethroid resistance","year":2017,"lang":"en","type":"article","venue":"Insect Biochemistry and Molecular Biology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; China Scholarship Council","keywords":"Pyrethroid; Deltamethrin; Sodium channel; Cypermethrin; Permethrin; Biology; Knockdown resistance; Biophysics; Toxicology; Genetics; Sodium; Chemistry; Pesticide; Cyfluthrin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136986,0.0005952575,0.0004948339,0.0003272494,0.0002937095,0.0003797797,0.0004222935,0.0007569679,0.002405704],"category_scores_gemma":[0.0004050176,0.0002302427,0.0006466746,0.0001969623,0.0009219723,0.0002997263,0.0005663583,0.001153906,0.0007064113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003833873,"about_ca_system_score_gemma":0.0002816928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000701981,"about_ca_topic_score_gemma":0.0008547185,"domain_scores_codex":[0.9996887,0.00007095069,0.00006157669,0.00004468045,0.00007490621,0.0000591298],"domain_scores_gemma":[0.9993914,0.0001526782,0.0001598787,0.00005712613,0.00004739782,0.0001914735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003590091,0.00003654998,0.0001896399,0.00001550348,0.00001370354,0.0002905981,0.00002047166,0.0001175304,0.9982578,0.0001670906,0.00001812711,0.0005139803],"study_design_scores_gemma":[0.0001584817,0.0004999189,0.01003372,0.00001583946,0.00008469762,0.001635924,0.00009543365,0.002556779,0.9836001,0.0001814794,0.001104109,0.00003341692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972474,0.0001099345,0.001544095,0.00007673165,0.00003701731,0.00001921561,0.0001499998,0.00004044265,0.0007752217],"genre_scores_gemma":[0.997995,0.00008523027,0.0007156239,0.00007095725,0.00001020348,0.0000129347,0.0002049456,0.00004378099,0.0008612492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002405704,"threshold_uncertainty_score":0.008047879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009763437294295721,"score_gpt":0.2733472737334672,"score_spread":0.2635838364391715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}