{"id":"W2575675571","doi":"10.1101/cshperspect.a027151","title":"Experimental Models of Inherited PrP Prion Diseases","year":2017,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Daiichi Sankyo Europe; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Rainwater Charitable Foundation; Sherman Fairchild Foundation; Henry M. Jackson Foundation; Glenn Foundation for Medical Research","keywords":"Medicine; Prion protein; Gerontology; Library science; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002175446,0.0003863862,0.001165759,0.0001969296,0.00008236617,0.00001761243,0.0005672692,0.000251761,0.00003912664],"category_scores_gemma":[0.0003392231,0.0003351335,0.0003060478,0.0001106794,0.0003309696,0.0000104041,0.0002892553,0.0002159702,0.000001677617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001197017,"about_ca_system_score_gemma":0.0002378849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005674721,"about_ca_topic_score_gemma":0.000002198692,"domain_scores_codex":[0.998209,0.0001292057,0.000501997,0.0006512058,0.0002380905,0.0002705206],"domain_scores_gemma":[0.9984193,0.00002794001,0.0004598977,0.0008685231,0.00008012958,0.0001442237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008793874,0.002993426,0.0003951586,0.04216555,0.002440879,0.000330658,0.001745852,0.0001109122,0.1148668,0.02896716,0.001396419,0.8037078],"study_design_scores_gemma":[0.001357534,0.0004931265,0.0002375692,0.02230965,0.0004501607,0.000002915004,0.0003722818,0.00006512459,0.00143841,0.00003788706,0.9725163,0.0007190522],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009942683,0.9974644,0.0001187796,0.00001834921,0.0001615981,0.00101783,0.00003798822,0.00001625299,0.0001705188],"genre_scores_gemma":[0.04322001,0.9557012,0.0001574781,0.00001380328,0.0005140942,0.0002701686,0.00001773881,0.00006155335,0.00004399958],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9711199,"threshold_uncertainty_score":0.9999101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08290549560443107,"score_gpt":0.3852757884520374,"score_spread":0.3023702928476064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}