{"id":"W2575675571","doi":"10.1101/cshperspect.a027151","title":"Experimental Models of Inherited PrP Prion Diseases","year":2017,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"Daiichi Sankyo Europe; National Institute on Aging; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Rainwater Charitable Foundation; Sherman Fairchild Foundation; Henry M. Jackson Foundation; Glenn Foundation for Medical Research","keywords":"Medicine; Prion protein; Gerontology; Library science; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007297923,0.00107082,0.001100549,0.001942888,0.0002820459,0.0007948705,0.0009489919,0.0009787411,0.002401848],"category_scores_gemma":[0.0003227607,0.0002171602,0.0004385156,0.0009593437,0.0005888259,0.00100286,0.0006787119,0.001896576,0.002274938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005199483,"about_ca_system_score_gemma":0.0006485005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000516074,"about_ca_topic_score_gemma":0.0009706925,"domain_scores_codex":[0.9997812,0.00003042981,0.00002413998,0.00003624415,0.0001040149,0.00002394986],"domain_scores_gemma":[0.9997802,0.00005947513,0.00004422262,0.00001195245,0.00006677817,0.00003734811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001386625,0.0001932218,0.0004468553,0.01450066,0.0001140294,0.0008056877,0.0001105422,0.0004020726,0.05211341,0.01223578,0.05375436,0.8651847],"study_design_scores_gemma":[0.00002068042,0.0001416693,0.0007490518,0.001494885,0.00009115099,0.002363488,0.00003548724,0.00009149395,0.006182174,0.002425845,0.986371,0.00003316479],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008333289,0.9920548,0.001471978,0.0003938239,0.000475224,0.00003189601,0.0001105131,0.00007326506,0.004555059],"genre_scores_gemma":[0.00256555,0.9933574,0.001146749,0.0003889484,0.0001784871,0.00004535628,0.0002048389,0.000007201842,0.002105515],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002401848,"threshold_uncertainty_score":0.008035004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08290549560443107,"score_gpt":0.3852757884520374,"score_spread":0.3023702928476064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}