{"id":"W2575675780","doi":"10.1139/bcb-2016-0053","title":"Lactoferrin inhibits melanogenesis by down-regulating MITF in melanoma cells and normal melanocytes","year":2017,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Microphthalmia-associated transcription factor; Melanin; Tyrosinase; Lactoferrin; MAPK/ERK pathway; Melanoma; Cell biology; Biology; Endocrinology; Phosphorylation; Epidermis (zoology); Extracellular; Internal medicine; Cancer research; Biochemistry; Medicine; Anatomy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001183354,0.0002230129,0.0002449511,0.0001643711,0.0001230613,0.0001782898,0.00008861875,0.0001994787,0.0005107684],"category_scores_gemma":[0.0000892732,0.00005993043,0.0001765159,0.00007934153,0.0001322234,0.0001282261,0.00009918914,0.0002930363,0.0001648874],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933543,"about_ca_system_score_gemma":0.0001132898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006014489,"about_ca_topic_score_gemma":0.0007044661,"domain_scores_codex":[0.9999093,0.00002239365,0.000007734966,0.0000139887,0.00002081811,0.00002570674],"domain_scores_gemma":[0.9999461,0.00001393446,0.00001172886,0.000007368032,0.000006355227,0.00001458947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005101592,0.00001540288,0.00006864143,0.00001178139,0.000001067631,0.00001970511,0.000005101599,0.00001385312,0.9992873,0.00001244795,0.000006233435,0.0005074813],"study_design_scores_gemma":[0.0000109118,0.0003006093,0.003225615,0.00000279191,0.000006404167,0.0001512972,0.0000148343,0.0003723581,0.9945506,0.00001304875,0.00134974,0.000001736442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939184,0.003905575,0.001410098,0.00005472155,0.00001729208,0.00001829668,0.00008436256,0.00003558141,0.0005556373],"genre_scores_gemma":[0.9962078,0.0009358251,0.001503823,0.00002974298,0.000008469807,0.00002431154,0.0001437679,0.000009587907,0.001136657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006014489,"threshold_uncertainty_score":0.001708746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00747373866504197,"score_gpt":0.234151686849351,"score_spread":0.2266779481843091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}