{"id":"W2575735043","doi":"10.1182/blood.v110.11.444.444","title":"Phase I/II Study of MGCD0103, an Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor, in Combination with 5-Azacitidine in Higher-Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML).","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; Nausea; Phases of clinical research; Histone deacetylase inhibitor; Oncology; Pharmacology; Gastroenterology; Clinical trial; Bone marrow; Histone deacetylase; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00115921,0.001443502,0.001608243,0.0006007327,0.0004493315,0.000849257,0.001178068,0.001547123,0.003005929],"category_scores_gemma":[0.0005263296,0.0007132595,0.001036013,0.0004483188,0.000990506,0.0005996281,0.0003408358,0.003173921,0.0008066415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009788506,"about_ca_system_score_gemma":0.002428984,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001649986,"about_ca_topic_score_gemma":0.00395189,"domain_scores_codex":[0.9996504,0.0001470558,0.00001554187,0.0000693258,0.0000377279,0.00007994295],"domain_scores_gemma":[0.99953,0.00005177062,0.00006830451,0.00003883006,0.0000325154,0.0002786621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.5238034,0.2195082,0.005115674,0.000854582,0.001076316,0.0003890206,0.0003155858,0.003750232,0.1366097,0.0008914712,0.008476527,0.09920935],"study_design_scores_gemma":[0.3945545,0.580722,0.006236139,0.00003446745,0.0003509854,0.0002607192,0.00005562953,0.001659028,0.01099012,0.0002810902,0.004828402,0.00002693015],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816413,0.002713107,0.00138423,0.0007474555,0.0002487488,0.007357999,0.001920094,0.0001724497,0.003814577],"genre_scores_gemma":[0.9734587,0.002958714,0.004905989,0.001602639,0.0002473502,0.005845825,0.004190244,0.00005976794,0.00673084],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003005929,"threshold_uncertainty_score":0.01005584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101789143580768,"score_gpt":0.2842914762356825,"score_spread":0.2732735847998748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}