{"id":"W2575735043","doi":"10.1182/blood.v110.11.444.444","title":"Phase I/II Study of MGCD0103, an Oral Isotype-Selective Histone Deacetylase (HDAC) Inhibitor, in Combination with 5-Azacitidine in Higher-Risk Myelodysplastic Syndrome (MDS) and Acute Myelogenous Leukemia (AML).","year":2007,"lang":"en","type":"article","venue":"Blood","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pyrogenesis (Canada)","funders":"","keywords":"Azacitidine; Medicine; Internal medicine; Myelodysplastic syndromes; Nausea; Phases of clinical research; Histone deacetylase inhibitor; Oncology; Pharmacology; Gastroenterology; Clinical trial; Bone marrow; Histone deacetylase; Biology; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000752811,0.0003305999,0.0004694006,0.0004790924,0.000144396,0.00001738954,0.0002121682,0.000267818,0.000009945436],"category_scores_gemma":[0.0001028132,0.0003306065,0.00004052165,0.0006631063,0.0002220577,0.00002907267,0.0001565754,0.0004395201,0.000002895364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002342241,"about_ca_system_score_gemma":0.0002939813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001049814,"about_ca_topic_score_gemma":0.007765723,"domain_scores_codex":[0.997483,0.0002514877,0.0005609245,0.0007275529,0.0004101959,0.0005668636],"domain_scores_gemma":[0.9989063,0.00005475801,0.0002046974,0.0004327534,0.0002015072,0.0002000473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003564654,0.02163034,0.01326085,0.00007118245,0.0002787511,0.001268091,0.001978361,0.00008349396,0.9550004,0.00001568618,0.00007184104,0.002776339],"study_design_scores_gemma":[0.05717475,0.06889101,0.04858387,0.0001032215,0.0002688013,0.0003526085,0.0009063977,0.0001084681,0.8226666,0.00003741772,0.0001346643,0.000772129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983254,0.0004094781,0.00007479769,0.00001585756,0.00007739566,0.0009085413,0.000044977,0.0000211544,0.0001223871],"genre_scores_gemma":[0.9991233,0.00005704219,0.0002908478,0.00001724145,0.00005779177,0.00006078766,0.0001366527,0.00005915563,0.000197154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1323337,"threshold_uncertainty_score":0.9999146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101789143580768,"score_gpt":0.2842914762356825,"score_spread":0.2732735847998748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}