{"id":"W2575801585","doi":"10.1016/j.jbo.2017.01.001","title":"Intra-tumor delivery of zoledronate mitigates metastasis-induced osteolysis superior to systemic administration","year":2017,"lang":"en","type":"article","venue":"Journal of bone oncology","topic":"Bone health and treatments","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Cancer Society Research Institute; Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Medicine; Systemic administration; Osteolysis; Lesion; Bone metastasis; Bisphosphonate; Metastasis; Internal medicine; Oncology; Urology; Surgery; Cancer; In vivo; Osteoporosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005800347,0.0001424474,0.0009932641,0.0002449889,0.0001286281,0.00001756895,0.0001200757,0.0001151859,0.00006346719],"category_scores_gemma":[0.0003262831,0.0001107395,0.0002082259,0.00006879043,0.00006589112,0.0001632421,0.00003441349,0.000235306,0.00002674285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002788805,"about_ca_system_score_gemma":0.001241692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000146714,"about_ca_topic_score_gemma":0.0001602658,"domain_scores_codex":[0.998241,0.000110399,0.0009881897,0.0001400268,0.0002726495,0.0002477566],"domain_scores_gemma":[0.9975147,0.0001001707,0.001222013,0.0003049053,0.0004463231,0.0004118695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01501545,0.002791286,0.1024919,0.00116598,0.002281162,0.01110104,0.001696697,0.000008484125,0.6106358,0.0001592486,0.001924944,0.250728],"study_design_scores_gemma":[0.03091573,0.05959724,0.4689859,0.002505055,0.005579567,0.04704525,0.002501841,0.00011841,0.373044,0.0001879608,0.008929013,0.0005901253],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918982,0.0005415278,0.000009480961,0.00625682,0.000490029,0.0003176751,0.00001252773,0.000006198607,0.000467583],"genre_scores_gemma":[0.9970984,0.0001158327,0.00201917,0.0004729234,0.0001350401,0.00001091827,0.000003157607,0.00001536229,0.0001292199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3664939,"threshold_uncertainty_score":0.4515825,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03558742255235599,"score_gpt":0.3532070227124463,"score_spread":0.3176196001600903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}