{"id":"W2575837388","doi":"10.1038/nature21386","title":"Integrated genomic and molecular characterization of cervical cancer","year":2017,"lang":"en","type":"article","venue":"Nature","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1580,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bank of Canada; BC Cancer Agency; Ottawa Hospital; Canada's Michael Smith Genome Sciences Centre; Ontario Institute for Cancer Research; London Health Sciences Centre","funders":"National Cancer Institute; National Human Genome Research Institute; Sidney Kimmel Comprehensive Cancer Center; National Institutes of Health; Hospital de Câncer de Barretos; Broad Institute; Research Institute, Nationwide Children's Hospital; Johns Hopkins University; Memorial Sloan-Kettering Cancer Center; University of South Carolina; Buck Institute for Research on Aging; Cedars-Sinai Medical Center; Massachusetts Institute of Technology; School of Medicine, Indiana University; London Health Sciences Centre; Harvard University; University of Texas MD Anderson Cancer Center; Beckman Research Institute, City of Hope; Universitetet i Bergen; Canada's Michael Smith Genome Sciences Centre; SRA International; Massachusetts General Hospital; Leidos; Nationwide Children's Hospital","keywords":"Cervical cancer; APOBEC; ARID1A; Cancer research; Biology; KRAS; Cancer; PTEN; Adenocarcinoma; CDKN2A; Gene; Oncology; Genetics; Medicine; Mutation; Colorectal cancer; Genome; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635112,0.0001868574,0.000326227,0.00194182,0.0002805069,0.0003269269,0.0002105841,0.0002027765,0.001302437],"category_scores_gemma":[0.0004106146,0.0001119313,0.0002787643,0.001276625,0.000144875,0.000134824,0.0004038767,0.0002588962,0.000364205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883215,"about_ca_system_score_gemma":0.0003444696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002779004,"about_ca_topic_score_gemma":0.004458559,"domain_scores_codex":[0.9997776,0.00001674069,0.00001407556,0.00007335568,0.00007906869,0.00003917852],"domain_scores_gemma":[0.9998007,0.00002773339,0.0000382414,0.00003435245,0.00006812718,0.00003078433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002137238,0.0000321994,0.0936119,0.0004316378,0.0001556014,0.0006769223,0.0002065053,0.0005027728,0.8429125,0.0002846371,0.0007464112,0.06022513],"study_design_scores_gemma":[0.00001933916,0.0002707113,0.7928412,0.00005621506,0.0003709653,0.008605376,0.0004141342,0.002286575,0.1637244,0.0006642525,0.03072193,0.0000247863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617293,0.009643619,0.01024493,0.0002313166,0.00002658426,0.0001648152,0.01141989,0.0002782914,0.006261213],"genre_scores_gemma":[0.9660505,0.003446361,0.01436932,0.0001345882,0.00003094577,0.0001243803,0.01415981,0.00004633689,0.001637754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002779004,"threshold_uncertainty_score":0.005525649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006225653241122503,"score_gpt":0.2828487311703093,"score_spread":0.2766230779291868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}