{"id":"W2575850575","doi":"10.1182/blood.v120.21.2624.2624","title":"Glutaminase Inhibition Selectively Slows the Growth of Primary Acute Myeloid Leukemia (AML) Cells with Isocitrate Dehydrogenase (IDH) Mutations.","year":2012,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Glutaminase; Isocitrate dehydrogenase; Glutamine; IDH1; IDH2; Glutaminolysis; Biology; Myeloid leukemia; Enzyme; Glutamate dehydrogenase; Biochemistry; Cancer research; Mutant; Glutamate receptor; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007585425,0.0003595464,0.0003650309,0.0001552733,0.00008309176,0.0002098401,0.0002358215,0.0002046676,0.001346166],"category_scores_gemma":[0.00008468877,0.0001076696,0.000205654,0.0001219574,0.0001164529,0.0001031912,0.0001454074,0.0004640175,0.0005810891],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001450446,"about_ca_system_score_gemma":0.0002084043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004459182,"about_ca_topic_score_gemma":0.00077915,"domain_scores_codex":[0.99994,0.000008366869,0.000007014415,0.00001383028,0.00001475159,0.00001592922],"domain_scores_gemma":[0.9999405,0.000009813504,0.00001385776,0.000006995593,0.000007075922,0.00002187106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077663,0.0002077318,0.0002539382,0.00007308168,0.00001384605,0.00007694696,0.00001604241,0.0001156374,0.9940447,0.00005777754,0.0001699978,0.003892589],"study_design_scores_gemma":[0.0002141425,0.003779921,0.004316583,0.000008532385,0.00003685665,0.0003299378,0.00002079736,0.0008693474,0.9864728,0.00002790387,0.003917666,0.000005454007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934264,0.00304557,0.0009350911,0.0001033065,0.0001123259,0.00006950276,0.0005262605,0.0001909733,0.001590591],"genre_scores_gemma":[0.9927385,0.001765411,0.001191797,0.00006410444,0.000017304,0.0000574474,0.0008280374,0.00002060234,0.003316671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001346166,"threshold_uncertainty_score":0.004503369,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01094866986124878,"score_gpt":0.2367595249846403,"score_spread":0.2258108551233915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}