{"id":"W2575904277","doi":"10.1161/circheartfailure.116.003222","title":"Composite End Points in Clinical Trials of Heart Failure Therapy","year":2017,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian VIGOUR Centre; University of Alberta","funders":"Servier; Canadian Institutes of Health Research; Alberta Innovates; Alberta Innovates - Health Solutions; Amgen","keywords":"Statistics; Composite index; Clinical trial; Rank (graph theory); Heart failure; Consistency (knowledge bases); Mann–Whitney U test; Medicine; Composite number; Index (typography); Mathematics; Physical therapy; Computer science; Econometrics; Composite indicator; Internal medicine; Artificial intelligence; Algorithm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2957881,0.001812895,0.004358075,0.005571735,0.0009777313,0.005624013,0.00221371,0.003926736,0.009467997],"category_scores_gemma":[0.5684909,0.001185148,0.00352263,0.006479745,0.004336086,0.005355719,0.005177441,0.009128178,0.002664339],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002181872,"about_ca_system_score_gemma":0.004001703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620432,"about_ca_topic_score_gemma":0.0004355419,"domain_scores_codex":[0.5646353,0.3954304,0.01699334,0.005851522,0.0164593,0.0006301466],"domain_scores_gemma":[0.5412602,0.3902155,0.02782105,0.02680362,0.01201363,0.001886012],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.004118304,0.0002999304,0.008860001,0.01301983,0.004777531,0.0002870133,0.001459038,0.01725306,0.0009789795,0.3810313,0.09316781,0.4747471],"study_design_scores_gemma":[0.002595361,0.002431897,0.00640755,0.005156591,0.001482137,0.0004777491,0.0003017283,0.05237783,0.001615757,0.8296313,0.09725193,0.0002701672],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.004924303,0.01984966,0.9423558,0.01299577,0.004780426,0.004820547,0.001373127,0.001080125,0.007820304],"genre_scores_gemma":[0.09470887,0.009819429,0.8472163,0.006312253,0.004947293,0.03222763,0.00124832,0.0006594034,0.002860455],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.704212,"threshold_uncertainty_score":0.8684187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.6457514187604767,"score_gpt":0.6072940481127969,"score_spread":0.03845737064767984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}