{"id":"W2575934766","doi":"10.1111/jdv.14128","title":"A randomized, double‐blind, placebo‐controlled, dose‐escalation first‐in‐man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, <scp>AVX</scp>001, in patients with mild to moderate plaque psoriasis","year":2017,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Placebo; Double blind; Phases of clinical research; Pharmacology; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003396031,0.002524393,0.003862725,0.0006469483,0.0006694134,0.0009442411,0.001553433,0.00191903,0.008230997],"category_scores_gemma":[0.002327246,0.001281393,0.001369619,0.0004604986,0.001721836,0.001236377,0.0004557719,0.002559905,0.001455863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006884847,"about_ca_system_score_gemma":0.001789836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005969529,"about_ca_topic_score_gemma":0.001306209,"domain_scores_codex":[0.9987413,0.0007284413,0.00005653645,0.000199175,0.0001021891,0.0001723808],"domain_scores_gemma":[0.9981736,0.000435146,0.0004583963,0.0002188412,0.0001637191,0.0005503693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9558461,0.02340122,0.0005893962,0.0003352319,0.000374378,0.00003592129,0.00007910295,0.0002046012,0.008545088,0.0000909259,0.0007359848,0.009761895],"study_design_scores_gemma":[0.9013703,0.09626703,0.001138455,0.000009622208,0.0001020194,0.00002756653,0.000007397626,0.0001499387,0.0005079112,0.00006159175,0.0003499234,0.000008320557],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9785186,0.001928587,0.001972484,0.0004951728,0.0004025581,0.01384294,0.001301406,0.0002627983,0.00127542],"genre_scores_gemma":[0.9548035,0.002298404,0.008042697,0.001697772,0.000758839,0.02266771,0.001926248,0.00008667688,0.007718099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008230997,"threshold_uncertainty_score":0.02753538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017783277983754,"score_gpt":0.2874614708630209,"score_spread":0.2572836380831834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}