{"id":"W2575934766","doi":"10.1111/jdv.14128","title":"A randomized, double‐blind, placebo‐controlled, dose‐escalation first‐in‐man study (phase 0) to assess the safety and efficacy of topical cytosolic phospholipase A2 inhibitor, <scp>AVX</scp>001, in patients with mild to moderate plaque psoriasis","year":2017,"lang":"en","type":"article","venue":"Journal of the European Academy of Dermatology and Venereology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Placebo; Double blind; Phases of clinical research; Pharmacology; Clinical trial; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340008,0.0002778999,0.001377655,0.0002679709,0.0003273597,0.00001753893,0.0005525777,0.0002289308,0.000005256748],"category_scores_gemma":[0.0004599754,0.0001541159,0.0001453529,0.0001116124,0.0005028213,0.0001227824,0.0002903083,0.0005453019,0.000004683166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002571543,"about_ca_system_score_gemma":0.00003897927,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003588208,"about_ca_topic_score_gemma":0.0001088593,"domain_scores_codex":[0.9956397,0.002553104,0.001112265,0.0002829799,0.00008842757,0.0003234798],"domain_scores_gemma":[0.9972817,0.001237623,0.001060664,0.0002754743,0.00007399917,0.00007056336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.524196,0.001451977,0.4675328,0.00002415349,0.0009522414,0.00004987608,0.003159477,0.0003158828,0.0003263942,0.0003720783,0.0001598732,0.001459246],"study_design_scores_gemma":[0.549116,0.0003183931,0.4469834,0.00009767212,0.000427573,0.0002127025,0.0001333118,0.00001500268,0.002228532,0.00004813094,0.0003324391,0.00008685633],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949676,0.0005790596,0.0000321789,0.002417355,0.0003187024,0.001454965,0.00001389138,0.000004369754,0.0002118268],"genre_scores_gemma":[0.9994097,0.000184875,0.00004327224,0.0001788598,0.00005236187,0.00002322453,0.000003827381,0.00001764687,0.00008619189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02491997,"threshold_uncertainty_score":0.6284666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03017783277983754,"score_gpt":0.2874614708630209,"score_spread":0.2572836380831834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}