{"id":"W2575979041","doi":"10.1038/celldisc.2016.53","title":"ATPase activity tightly regulates RecA nucleofilaments to promote homologous recombination","year":2017,"lang":"en","type":"article","venue":"Cell Discovery","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Natural Science Foundation of China; University of Wisconsin-Madison; Chinese Academy of Sciences; Memorial Sloan-Kettering Cancer Center; National Science Foundation","keywords":"RAD51; Homologous recombination; Nuclease; ATP hydrolysis; Mutant; DNA; Chemistry; ATPase; In vitro; Recombination; Cell biology; Molecular biology; Homologous chromosome; DNA repair; Nucleotide; Biophysics; Biology; Biochemistry; Gene; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001877002,0.0002477447,0.0001480616,0.0001683505,0.0001457374,0.0004451931,0.0002296492,0.0002439214,0.0007164682],"category_scores_gemma":[0.0001973972,0.0001820801,0.0001367976,0.00008300012,0.0002751996,0.0002157399,0.0002643689,0.0003436359,0.0003580524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003221882,"about_ca_system_score_gemma":0.000125319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003115162,"about_ca_topic_score_gemma":0.0003485099,"domain_scores_codex":[0.9998332,0.00003182198,0.00001425158,0.00004379246,0.00004413059,0.00003275074],"domain_scores_gemma":[0.9997193,0.00005904218,0.00009465673,0.00001993745,0.00003262961,0.00007439235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003867839,0.00001084178,0.0001562228,0.000007402662,0.000001548572,0.0000164297,0.000004346533,0.00003092979,0.9992434,0.00009733275,0.00001121573,0.0003816308],"study_design_scores_gemma":[0.000005510216,0.00004752498,0.003494644,0.000003527288,0.000003030973,0.00009599513,0.00001470365,0.001376135,0.994046,0.00006562339,0.0008445707,0.000002729672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995944,0.0007376172,0.002485672,0.00004691333,0.00001057896,0.000009137607,0.00006865615,0.00004958477,0.0006478224],"genre_scores_gemma":[0.9986247,0.00008885373,0.0007670905,0.000008460328,0.000002647382,0.00000435753,0.00005531241,0.000009438962,0.0004393227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007164682,"threshold_uncertainty_score":0.002396882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01016779302509597,"score_gpt":0.2477907675957322,"score_spread":0.2376229745706362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}