{"id":"W2576030387","doi":"10.15252/msb.20167067","title":"Interactome disassembly during apoptosis occurs independent of caspase cleavage","year":2017,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Interactome; Biology; Apoptosis; Caspase; Cleavage (geology); Cell biology; Caspase 3; Computational biology; Caspase 7; Bioinformatics; Biochemistry; Programmed cell death; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448673,0.0001979561,0.0003022809,0.0006414634,0.0002989538,0.0004985941,0.0002125,0.000264014,0.0007001194],"category_scores_gemma":[0.0005114819,0.0001633879,0.0002443842,0.0004839944,0.0002394826,0.0006219367,0.0003665225,0.000508102,0.0003204434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004130729,"about_ca_system_score_gemma":0.0001878392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004314705,"about_ca_topic_score_gemma":0.0007032902,"domain_scores_codex":[0.9995833,0.00003915536,0.00002406368,0.0001064394,0.0001722737,0.00007469422],"domain_scores_gemma":[0.9995365,0.00008331495,0.0001914979,0.00003771151,0.00007437975,0.00007660094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000185126,0.00001694046,0.00486393,0.00003129961,0.00001619127,0.00007813778,0.00003428811,0.00006931813,0.9924282,0.00007582363,0.0000361917,0.002164385],"study_design_scores_gemma":[0.00001226806,0.0001952033,0.3303117,0.000008497692,0.00003808125,0.0009211758,0.0001343593,0.002139198,0.6640406,0.0002863904,0.001897242,0.00001525129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956776,0.000910204,0.002456109,0.00003761249,0.000004896813,0.000009471649,0.0003560836,0.00005264494,0.0004952515],"genre_scores_gemma":[0.9961305,0.0004077735,0.001938941,0.0000427538,0.000005461996,0.00002931308,0.0008388606,0.00001416871,0.0005923639],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007001194,"threshold_uncertainty_score":0.0029971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009634383851861399,"score_gpt":0.2684113142377624,"score_spread":0.258776930385901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}