{"id":"W2576030387","doi":"10.15252/msb.20167067","title":"Interactome disassembly during apoptosis occurs independent of caspase cleavage","year":2017,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"British Columbia Knowledge Development Fund; National Health and Medical Research Council; Medical Research Council; Canadian Institutes of Health Research; Michael Smith Health Research BC; Canada Excellence Research Chairs, Government of Canada; Canada Foundation for Innovation","keywords":"Interactome; Biology; Apoptosis; Caspase; Cleavage (geology); Cell biology; Caspase 3; Computational biology; Caspase 7; Bioinformatics; Biochemistry; Programmed cell death; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001943542,0.0001959344,0.0002861606,0.00007372819,0.0001721121,0.0000482686,0.0003976452,0.0003129723,0.000007298012],"category_scores_gemma":[0.00007959452,0.0001749001,0.0001546107,0.000028672,0.0001097545,0.000006456469,0.0002897734,0.00008162646,0.000008994208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001996232,"about_ca_system_score_gemma":0.00002933961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003556194,"about_ca_topic_score_gemma":0.00002596028,"domain_scores_codex":[0.9987333,0.0001145275,0.000344141,0.0004234976,0.0001070248,0.0002774877],"domain_scores_gemma":[0.9985154,0.000005595815,0.0003922891,0.0009165895,0.00008315803,0.00008696122],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006685557,0.00004177157,0.003430062,0.00006670496,0.00009609801,0.00001184166,0.00002691464,0.0000423989,0.9943027,0.001049066,0.00003260626,0.0008329978],"study_design_scores_gemma":[0.0006598386,0.0002362919,0.01078202,0.00004409394,0.00002893194,0.00004727614,0.00006352102,0.00008532171,0.9867055,0.00004211226,0.001079998,0.0002250364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929073,0.0006844466,0.004323438,0.00004175316,0.0008574913,0.0002739069,0.00003197499,0.0000119369,0.0008677719],"genre_scores_gemma":[0.9992663,0.00007988802,0.00007872671,0.00002006924,0.0001462776,0.00002976793,0.0001071904,0.00002754383,0.0002441964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007597125,"threshold_uncertainty_score":0.7132221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009634383851861399,"score_gpt":0.2684113142377624,"score_spread":0.258776930385901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}