{"id":"W2576153484","doi":"10.1126/science.aag2355","title":"The role of dimer asymmetry and protomer dynamics in enzyme catalysis","year":2017,"lang":"en","type":"article","venue":"Science","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":205,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Chemistry; Dimer; Enzyme; Enzyme catalysis; Substrate (aquarium); Catalysis; Stereochemistry; Dehalogenase; Biochemistry; Biology; Organic chemistry; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002962566,0.0001421664,0.0002207054,0.0001942791,0.0003035027,0.0005962944,0.0003247097,0.0003494273,0.0006480875],"category_scores_gemma":[0.0009374816,0.0002198857,0.0001095729,0.0001236848,0.0004665155,0.001029669,0.0002625047,0.0003313794,0.0001302428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004560476,"about_ca_system_score_gemma":0.000262523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000494266,"about_ca_topic_score_gemma":0.0005216815,"domain_scores_codex":[0.9999287,0.00001534767,0.000003990387,0.00002317955,0.00001505965,0.00001379699],"domain_scores_gemma":[0.9997297,0.0001211006,0.00005487676,0.00003167065,0.00002102449,0.0000416995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008760666,0.0002407777,0.0358029,0.0001569716,0.00006777315,0.000574315,0.0007688517,0.08028001,0.7991055,0.03080507,0.0004971555,0.05082466],"study_design_scores_gemma":[0.00008761405,0.0002675748,0.04223039,0.00002088693,0.00006752865,0.000596324,0.0004531967,0.7230157,0.2003947,0.03048712,0.002294453,0.00008455399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941751,0.0003202754,0.004619638,0.00008276854,0.000004007446,0.000003027458,0.00001990896,0.00004168605,0.0007336052],"genre_scores_gemma":[0.9994004,0.00009467167,0.0004197728,0.000005337395,0.000001412405,0.000001600423,0.000009869907,0.000006425382,0.00006057427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006480875,"threshold_uncertainty_score":0.003308892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002840330740208136,"score_gpt":0.2443554176107917,"score_spread":0.2415150868705836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}