{"id":"W2576454162","doi":"10.2174/1381612822666161227152200","title":"Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury","year":2017,"lang":"en","type":"article","venue":"Current Pharmaceutical Design","topic":"Spinal Cord Injury Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada); Université de Montréal; Centre hospitalier universitaire de Québec; McGill University Health Centre","funders":"","keywords":"Tetraplegia; Medicine; Paraplegia; Spinal cord injury; Spinal cord; Anesthesia; Levodopa; Physical medicine and rehabilitation; Carbidopa; Placebo; Internal medicine; Parkinson's disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004521522,0.001158572,0.003626276,0.0008033477,0.0008255506,0.000481265,0.0009761899,0.0001776469,0.0004494628],"category_scores_gemma":[0.00119991,0.0007422225,0.0003141841,0.0006299138,0.00180527,0.000523589,0.0004239901,0.002166915,0.0001039305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003829061,"about_ca_system_score_gemma":0.0008160739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000155749,"about_ca_topic_score_gemma":0.00005828181,"domain_scores_codex":[0.9915806,0.001613538,0.001553002,0.001695704,0.001878446,0.00167872],"domain_scores_gemma":[0.994511,0.00135673,0.0006489778,0.001514856,0.000569917,0.001398527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9578009,0.004931282,0.002120858,0.0004295667,0.0009476799,0.001379902,0.0001090036,0.000007435216,0.003221911,0.0001177543,0.0001246302,0.02880908],"study_design_scores_gemma":[0.9062093,0.06864273,0.005424669,0.001179452,0.002153903,0.0003370636,0.0001164244,0.01240345,0.0006887179,0.00001578076,0.001875667,0.0009527688],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514399,0.001594587,0.01452792,0.001153703,0.0004418837,0.03009966,0.00007727719,0.0001959771,0.0004690634],"genre_scores_gemma":[0.9953228,0.0006478321,0.001212433,0.0001798498,0.0004087738,0.001800245,0.0000345615,0.0001573327,0.000236128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06371144,"threshold_uncertainty_score":0.9995029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2733489939426978,"score_gpt":0.4900400122785891,"score_spread":0.2166910183358913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}