{"id":"W2576454162","doi":"10.2174/1381612822666161227152200","title":"Double-Blind, Placebo-Controlled, Randomized Phase I/IIa Study (Safety and Efficacy) with Buspirone/Levodopa/Carbidopa (SpinalonTM) in Subjects with Complete AIS A or Motor-Complete AIS B Spinal Cord Injury","year":2017,"lang":"en","type":"article","venue":"Current Pharmaceutical Design","topic":"Spinal Cord Injury Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nordic Life Science Pipeline (Canada); Université de Montréal; Centre hospitalier universitaire de Québec; McGill University Health Centre","funders":"","keywords":"Tetraplegia; Medicine; Paraplegia; Spinal cord injury; Spinal cord; Anesthesia; Levodopa; Physical medicine and rehabilitation; Carbidopa; Placebo; Internal medicine; Parkinson's disease; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002540492,0.002041923,0.003912134,0.0006917666,0.000859588,0.001045813,0.001220564,0.002329882,0.005368819],"category_scores_gemma":[0.001704004,0.001051728,0.001115853,0.0006422272,0.002198524,0.001130234,0.0004190153,0.002157233,0.001377508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000694017,"about_ca_system_score_gemma":0.002114475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117809,"about_ca_topic_score_gemma":0.002225079,"domain_scores_codex":[0.9990265,0.0004777804,0.00007853407,0.000178775,0.00008416192,0.0001542181],"domain_scores_gemma":[0.9985399,0.0002732029,0.0002829154,0.0001477504,0.0001675032,0.0005886804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9652483,0.01854008,0.0004985072,0.0003809124,0.0003130579,0.00003432193,0.00005750911,0.0001575468,0.006590194,0.00005336313,0.00041126,0.00771493],"study_design_scores_gemma":[0.8143238,0.1822192,0.001864351,0.00001443594,0.0001671917,0.00002515383,0.00001916466,0.0002308561,0.0006179641,0.00006407537,0.0004415356,0.00001225496],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788066,0.003006913,0.001342948,0.0004851363,0.0005207941,0.01256047,0.001141232,0.0002025148,0.001933385],"genre_scores_gemma":[0.9715276,0.002637799,0.003350424,0.001567752,0.0009872649,0.01381786,0.001376824,0.00004480033,0.004689783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005368819,"threshold_uncertainty_score":0.01796055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2733489939426978,"score_gpt":0.4900400122785891,"score_spread":0.2166910183358913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}