{"id":"W2576519591","doi":"10.1021/acschemneuro.6b00310","title":"Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Nova Scotia Health Research Foundation; Huntington Society of Canada","keywords":"Allosteric regulation; Allosteric modulator; Inverse agonist; Agonist; Pharmacology; Chemistry; Cannabinoid receptor; Enantiomer; Intrinsic activity; Cannabinoid; Receptor; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334517,0.0002464741,0.0001945692,0.00008328197,0.0001159864,0.0001851532,0.0002493963,0.0001437014,0.001896315],"category_scores_gemma":[0.0001240939,0.0001037207,0.0002120462,0.0001088384,0.0001568142,0.000112241,0.000194258,0.0003946306,0.0005982145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002211293,"about_ca_system_score_gemma":0.0001819236,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005437689,"about_ca_topic_score_gemma":0.0009443274,"domain_scores_codex":[0.9999162,0.00001366014,0.000007750778,0.00001910467,0.00002245381,0.00002084762],"domain_scores_gemma":[0.9999719,0.000002890827,0.00000802028,0.000007101333,0.000004467868,0.000005749118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002249468,0.00004598553,0.000195147,0.0000587703,0.000009981137,0.0001368553,0.00002642743,0.0002733708,0.9938515,0.0005951901,0.0002183763,0.004363438],"study_design_scores_gemma":[0.00005996391,0.0003637699,0.001288543,0.000007017966,0.00002318518,0.0007805054,0.00002502559,0.001774825,0.9867522,0.0001001725,0.00880988,0.00001490384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841978,0.001506893,0.005017642,0.0001710371,0.0000531813,0.00006974481,0.0005618235,0.0001642434,0.008257681],"genre_scores_gemma":[0.9907595,0.001356788,0.00410213,0.0001428104,0.00001630886,0.00003193978,0.0005267858,0.00003474305,0.003029085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001896315,"threshold_uncertainty_score":0.006343842,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497986942619979,"score_gpt":0.315762591422756,"score_spread":0.2807827219965562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}