{"id":"W2576519591","doi":"10.1021/acschemneuro.6b00310","title":"Enantiospecific Allosteric Modulation of Cannabinoid 1 Receptor","year":2017,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Eye Institute; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Nova Scotia Health Research Foundation; Huntington Society of Canada","keywords":"Allosteric regulation; Allosteric modulator; Inverse agonist; Agonist; Pharmacology; Chemistry; Cannabinoid receptor; Enantiomer; Intrinsic activity; Cannabinoid; Receptor; Stereochemistry; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001693663,0.0001064856,0.0002072059,0.00005851859,0.0001782179,0.00007001521,0.0004467967,0.00006537345,0.00006350416],"category_scores_gemma":[0.0008569213,0.00008717891,0.00007857598,0.0001583295,0.0006633014,0.0001905566,0.0002108448,0.0001808818,0.00001504276],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004126186,"about_ca_system_score_gemma":0.0001202472,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004410862,"about_ca_topic_score_gemma":8.334424e-7,"domain_scores_codex":[0.9985231,0.0000135533,0.0002250739,0.0003777621,0.0005570684,0.0003034923],"domain_scores_gemma":[0.9987188,0.000005574316,0.0001405762,0.0007678978,0.0001698576,0.0001973014],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000572565,0.00008628757,0.004657256,0.00003907077,0.000001072064,0.000007634315,0.00002540063,0.000001186066,0.9815964,0.0001203999,0.009592054,0.003815964],"study_design_scores_gemma":[0.0004674257,0.0001427952,0.1897543,0.00003206245,0.000006743984,0.00002908356,0.000008546864,0.0004146484,0.7854248,0.00005035367,0.02357012,0.00009909615],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892311,0.00002460573,0.00002952546,0.008251628,0.0002710937,0.000208979,0.000009445949,0.00002204662,0.001951628],"genre_scores_gemma":[0.9931787,0.00004155183,0.0001096492,0.0002723986,0.0001032014,0.00001361394,0.000004456558,0.00001291647,0.00626353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1961716,"threshold_uncertainty_score":0.3555053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03497986942619979,"score_gpt":0.315762591422756,"score_spread":0.2807827219965562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}