{"id":"W2576601447","doi":"10.1182/blood.v112.11.686.686","title":"Comprehensive Genomic Screens Reveal Multiple Modes of Action of the PLZF-RAR-α Oncoprotein","year":2008,"lang":"en","type":"article","venue":"Blood","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital","funders":"","keywords":"Biology; Promoter; Acute promyelocytic leukemia; Gene; Transcription factor; Molecular biology; Genetics; Gene expression; Retinoic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603538,0.0004617533,0.0003273133,0.0005582405,0.0001974019,0.0003010078,0.0001794734,0.0001782186,0.001460815],"category_scores_gemma":[0.0002056144,0.0001764811,0.0004070602,0.0005447857,0.0002206426,0.00008541294,0.0002849727,0.0003216327,0.0005809319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417972,"about_ca_system_score_gemma":0.0002100701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006655621,"about_ca_topic_score_gemma":0.001938729,"domain_scores_codex":[0.9997651,0.00002275734,0.00001475478,0.00006936306,0.00008153962,0.00004643919],"domain_scores_gemma":[0.999837,0.00005330399,0.00004766469,0.00001963953,0.00001157552,0.00003078145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009114113,0.00001148421,0.00104442,0.00002309689,0.00001564321,0.0001056437,0.000007960436,0.0001374983,0.9971005,0.00002940082,0.00003567426,0.001397403],"study_design_scores_gemma":[0.00005541222,0.0005751004,0.08915081,0.00001417772,0.0002417227,0.001864157,0.00007438417,0.002966796,0.8987827,0.0001668786,0.006092401,0.00001539244],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850153,0.001355247,0.007198368,0.00008000826,0.00001099824,0.00006505947,0.004876497,0.0003248689,0.001073573],"genre_scores_gemma":[0.9861603,0.0007958194,0.004566425,0.00007391557,0.000008240198,0.00004711826,0.006600942,0.00005367932,0.001693506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001460815,"threshold_uncertainty_score":0.004886925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02444172262291396,"score_gpt":0.2356459372236057,"score_spread":0.2112042146006917,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}